DNA 'Nanoclew' Delivers CRISPR-Cas9 Gene-Editing Tool Directly Into Cells (image)
Caption
When the nanoclew comes into contact with a cell, the cell absorbs the nanoclew completely -- swallowing it and wrapping it in a protective sheath called an endosome. But the nanoclews are coated with a positively charged polymer that breaks down the endosome, setting the nanoclew free inside the cell. The CRISPR-Cas9 complexes can then free themselves from the nanoclew to make their way to the nucleus.
Credit
North Carolina State University
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