News Release

Unlocking the genetic code of peppers: New study reveals insights into domestication and diversity

Peer-Reviewed Publication

Boyce Thompson Institute

ITHACA, NY, September 11, 2023- Peppers are a versatile, flavorful, and widely popular crop, used not only as a healthy food source but also for their medicinal properties. In a pioneering study recently published in Nature Communications, an international team of researchers, including scientists from the Boyce Thompson Institute, has sequenced the genomes of key cultivated and wild pepper species, offering unprecedented insights into pepper evolution, domestication, and genetic diversity. 

"Our analyses have allowed us to identify genes associated with critical traits, including fruit shape, flavor, and stress responses. This opens up a world of possibilities for agricultural advancements and the development of more resilient, flavorful varieties," said Professor Zhangjun Fei, one of the study's lead authors. 

The Capsicum genus, commonly called pepper or paprika, belongs to the nightshade family and includes about 35 species. The researchers discovered that the two main domesticated species have been selectively bred in different ways, affecting traits like fruit size, shape, and spiciness. They also found that some species have borrowed genetic traits from others, which could help them better resist pests and environmental stress.  

"Our findings suggest that the pepper's domestication is more complex than previously thought," said Fei. "The unique genomic regions we've identified could be significant in developing pepper varieties tailored for specific environmental conditions and those with enhanced fruit quality." 

The researchers began by assembling high-quality genomes for three pepper species using advanced sequencing technologies. They constructed a comprehensive graph pan-genome using these genomes as a basis. The team then resequenced the genomes of 500 pepper varieties, covering all five domesticated species and their wild relatives. Using these extensive data, they created a detailed variation map to analyze the genetic differences between these species.  

"Our study provides valuable genomic resources that deepen our understanding of pepper genetics, facilitating future functional studies and greatly enhancing breeding efforts," concluded Fei.

The resulting pepper genome sequence and variants database can be searched, viewed, and analyzed and is maintained by the Fei Lab

This research was supported by grants from the Laboratory of Lingnan Modern Agriculture Project (NT2021004), the National Natural Science Foundation of China (U19A2028, U21A20230 and 32130097), the Science and Technology Innovation Program of Hunan Province, China (2021NK1006 and 2021JC0007), and the US National Science Foundation (IOS-1855585 to Z.F.).

About Boyce Thompson Institute
Founded in 1924, Boyce Thompson Institute (BTI) is a premier plant biology and life sciences research institution located in Ithaca, New York. BTI scientists conduct investigations into fundamental research with the goals of increasing food security, improving environmental sustainability, and making basic discoveries that will enhance human health. Throughout this work, BTI is committed to inspiring and educating students and to providing advanced training for the next generation of scientists. BTI is an independent nonprofit research institute that is affiliated with Cornell University. For more information, please visit

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