News Release

Chronic comorbidities raise hospitalization risk in dementia

Chronic comorbidities among patients with dementia are common and linked to greater risk of hospitalizations and emergency department visits

Peer-Reviewed Publication


Most community-dwelling older adults with dementia have multiple other chronic diseases, which are linked to increased risk of hospitalizations and emergency department (ED) visits, a new retrospective study has concluded. The study, by Luke Mondor and Colleen Maxwell of the Institute for Clinical Evaluative Sciences, Toronto, Canada, and colleagues, is published in PLOS Medicine's Special Issue on Dementia.

The occurrence of multiple chronic conditions in an individual (multimorbidity) has been linked to poor outcomes in previous studies. To study this association among people with dementia, the researchers analyzed data collected in 2012 from 30,112 home-care clients with dementia in Ontario, Canada. The dataset included information on whether each patient had any of 16 common chronic conditions, the continuity of any care they received from physicians--based on the number of clinicians seen over the previous two years--and the timing of hospitalizations and ED visits.

The researchers found that 89% of the cohort had 2 or more chronic conditions in addition to dementia and 35% had 5 or more conditions. Their analysis showed that as multimorbidity increased, risk of hospitalizations and ED visits also went up. For example, the risk of hospitalization was 88% greater (95% CI: 1.72-2.05, p<0.001) and the risk of ED visits 63% greater (95% CI: 1.51-1.77, p<0.001) among those with five or more conditions compared to those with only dementia or with one other condition. After adjustment for demographic and health measures, there was no evidence that high vs. low continuity of care was associated with risk of hospitalizations and ED visits at any level of multimorbidity. The research was limited by its retrospective nature and the fact that hospitalizations and ED visits were not stratified by specific reason.

"With increases in life expectancy, improvements to disease detection, and a shift to community-based care, use of home care services and the prevalence of multimorbidity among older persons with dementia will likely rise," the authors say. "Data from this study may be useful in identifying at-risk individuals and prioritizing the deployment of limited health care resources."



This research was supported by grants from the Ontario Ministry of Health and Long-Term Care (MOHLTC) and the Ontario SPOR Support Unit to the Health System Performance Research Network (HSPRN: fund #06034, recipient WPW), and by the Institute for Clinical Evaluative Sciences (ICES), which is also funded by an annual grant from the MOHLTC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests:

The authors have declared that no competing interests exist.


Mondor L, Maxwell CJ, Hogan DB, Bronskill SE, Gruneir A, Lane NE, et al. (2017) Multimorbidity and healthcare utilization among home care clients with dementia in Ontario, Canada: A retrospective analysis of a population-based cohort. PLoS Med 14(3): e1002249. doi:10.1371/journal.pmed.1002249

Author Affiliations:

Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Health System Performance Research Network, Toronto, Ontario, Canada
School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada
School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada
Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
Division of Geriatric Medicine, University of Calgary, Calgary, Alberta, Canada
Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada
Department of Family Medicine, University of Alberta, Edmonton, Alberta, Canada
Toronto Rehabilitation Institute, Toronto, Ontario, Canada


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