News Release

Hot flashes linked to increased risk of hip fracture

Large cohort study reveals association between menopausal symptoms and bone health

Peer-Reviewed Publication

The Endocrine Society

Washington, DC--Women who experience moderate to severe hot flashes and night sweats during menopause tend to have lower bone mineral density and higher rates of hip fracture than peers who do not have menopausal symptoms, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Menopause is the life stage when a woman's ovaries stop producing hormones and her menstrual periods stop. About 60 percent of women experience hot flashes, which can last for several years.

Postmenopausal women face a greater risk of developing osteoporosis, a condition in which bones become structurally weak and more likely to break, than either younger women or men.

The risk for this group is higher because the menopausal transition speeds the body's normal process of bone loss. In postmenopausal women, the body tends to breaks down old bone tissue faster than it can be replaced.

"Our findings suggest women who exhibit moderate or severe menopausal symptoms are more likely to have issues with bone health than their peers," said one of the study's authors, Carolyn J. Crandall, MD, MS, of the David Geffen School of Medicine at the University of California, Los Angeles. "This is the first large cohort study to examine the relationship between menopausal symptoms and bone health in menopausal women."

The prospective cohort study examined data from 23,573 participants in the Women's Health Initiative (WHI) Clinical Trial. The participants were women between the ages of 50 and 79. The study, which was conducted at 40 clinical centers across the country, tracked women's annual visits for 8 years, on average.

Participants asked about their menopausal symptoms, including hot flashes and night sweats, during the initial visit. WHI participants then were monitored for fractures during the follow-up period. Among the participants, 4,867 had their bone mineral density measured as part of a sub-study.

The analysis found women who reported having moderate or severe hot flashes when they entered the study were more likely to fracture a hip during the follow-up period than women who had no menopausal symptoms. After researchers adjusted for age, body mass index and demographic factors, they found women who had moderate to severe menopausal symptoms had lower bone mass density at the neck and spine during the follow-up period than women with no symptoms.

"More research is needed to illuminate the connection between bone health and menopausal symptoms such as hot flashes," said Crandall. "Improved understanding would help clinicians advise women on how to better prevent osteoporosis and other bone conditions. Women who have hot flashes and want to protect their bones may benefit from healthy lifestyle habits such as avoiding smoking and excessive alcohol consumption, exercising and getting sufficient calcium and vitamin D."


Other authors of the study include: Aaron Aragaki and Andrea LaCroix of the Fred Hutchinson Cancer Research Center in Seattle, WA; Jane A. Cauley of the University of Pittsburgh in Pittsburgh, PA; JoAnn E. Manson of Brigham and Women's Hospital and Harvard Medical School in Boston, MA; Erin LeBlanc of Kaiser Permanente in Portland, OR; Robert Wallace of the University of Iowa College of Public Health in Iowa City, IA; Jean Wactawski-Wende of the State University of New York in Buffalo, NY; Mary Jo O'Sullivan of the University of Miami's Miller School of Medicine in Miami, FL; Mara Vitolins of Wake Forest School of Medicine in Winston-Salem, NC; and Nelson B. Watts of Mercy Health and Osteoporosis and Bone Health Services in Cincinnati, OH.

The WHI Clinical Trial was supported by the National Institutes of Health's National Heart, Lung, and Blood Institute.

The study, "Associations of Menopausal Vasomotor Symptoms with Fracture Incidence," was published online, ahead of print.

Founded in 1916, the Endocrine Society is the world's oldest, largest and most active organization devoted to research on hormones and the clinical practice of endocrinology. Today, the Endocrine Society's membership consists of over 18,000 scientists, physicians, educators, nurses and students in 122 countries. Society members represent all basic, applied and clinical interests in endocrinology. The Endocrine Society is based in Washington, DC. To learn more about the Society and the field of endocrinology, visit our site at Follow us on Twitter at!/EndoMedia.

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