News Release

Arsenic exposure in us public drinking water declines following new EPA regulations

Study shows federal government plays critical role in protecting human health

Peer-Reviewed Publication

Columbia University's Mailman School of Public Health

New research conducted at Columbia University's Mailman School of Public Health found that exposure to arsenic in drinking water was significantly reduced among Americans using public water systems following the Environmental Protection Agency (EPA) regulation on maximum levels of arsenic. Compliance with the regulation led to a decline of 17 percent in levels of urinary arsenic, equivalent to an estimated reduction of over 200 cases of lung and bladder disease every year. However, there were no improvements in arsenic exposure rates among users of private wells, which are not federally regulated. The findings reported in The Lancet Public Health confirm the critical role of federal drinking water regulations in decreasing toxic exposures and protecting human health.

This is the first study to evaluate the impact of the 2006 implementation of the maximum contaminant level on reducing arsenic exposure at the individual level or by using biomarker data.

"EPA regulation was associated with a significant decrease in urinary arsenic concentrations among Americans who use public water systems," said Anne Nigra, ScM, in the Mailman School's Department of Environmental Health Sciences, and the study's lead author. "Levels of arsenic in private wells, estimated to provide water to roughly 45.5 million Americans, vary significantly throughout the U.S. Because of the cost of testing and treating contaminated water, private well water users remain inadequately protected against arsenic exposure in drinking water, especially residents of lower socio-economic status."

Arsenic is an established carcinogen and naturally occurs in drinking water across the U.S. In 2006, public water systems were required to meet the new EPA 10 μg/L regulatory limit for the maximum arsenic level in drinking water, down from 50 μg/L. In the Southwest, many cities' public water supplies come from water sources with naturally high levels of arsenic, including Los Angeles, Albuquerque, Scottsdale and Tucson.

The researchers compared data from 14,127 participants in the National Health and Nutrition Examination Survey (NHANES) between 2003 and 2014 who tested for dimethylarsinate (DMA) - the main metabolite of inorganic arsenic in humans. They adjusted for other sources of arsenic such as diet and smoking. Arsenic was measured in spot urine samples collected during the examination in a one-third random subsample of participants 6 years of age or older.

Among public water users - approximately 70 percent of participants-- arsenic levels decreased from 3.01 μg/L in 2003-2004 to 2.49 μg/L in 2013-2014, or by 17 percent.

"The 17 percent reduction in water arsenic exposure for public water users represents a significant exposure reduction when applied at the population level," said Ana Navas-Acien, MD, PhD, professor of Environmental Health Sciences at the Mailman School, and co-author. "The decline was strongest among Mexican-Americans and supports the recent infrastructure investments in many cities in the Southwest that focused on ensuring water arsenic below 10 μg/L."

The decrease was only observed after 2009-2010, consistent with the regulatory compliance process under the Safe Drinking Water Act, which required time for testing, and time to address the problem by changing the source or installing water treatment.

The authors estimate that the reduction in exposure to arsenic is equivalent to a reduction of 200 cases of lung and bladder cancer per year, but could be as many as 900 cases.

There was no change recorded among well water users. It has been estimated that 1.7 million Americans are at risk of exposure to arsenic above the maximum contaminant level, >10 μg/L and 3.8 million to arsenic > 5 μg/L in household well water. The authors note that efforts to address arsenic levels in private wells vary between states. "To date, no state government requires homeowners to install treatment systems to reduce arsenic if test results for arsenic exceed these contaminant levels. Continuing efforts for additional state and federal initiatives are critical to help families sample, test, and address arsenic exposure from unregulated private wells," added Navas-Acien.


Co-authors of the study are Tiffany R. Sanchez, PhD, and Joseph Graziano, PhD, Mailman School of Public Health; Keeve E. Nachman, PhD, Johns Hopkins Bloomberg School of Public Health; David Harvey, MPH, Commissioned Corps Officer of the U.S. Public Health Service; and Steven N. Chillrud, PhD, Lamont-Doherty Earth Observatory, Columbia University.

The study is supported by the National Institute of Environmental Health Sciences (1R01ES025216, R01ES021367, 5P30ES009089, P42ES010349, and 5T32ES007322.

Columbia University's Mailman School of Public Health

Founded in 1922, Columbia University's Mailman School of Public Health pursues an agenda of research, education, and service to address the critical and complex public health issues affecting New Yorkers, the nation and the world. The Mailman School is the third largest recipient of NIH grants among schools of public health. Its over 450 multi-disciplinary faculty members work in more than 100 countries around the world, addressing such issues as preventing infectious and chronic diseases, environmental health, maternal and child health, health policy, climate change & health, and public health preparedness. It is a leader in public health education with over 1,300 graduate students from more than 40 nations pursuing a variety of master's and doctoral degree programs. The Mailman School is also home to numerous world-renowned research centers including ICAP and the Center for Infection and Immunity. For more information, please visit

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