News Release

Chronic medical conditions may place youth at an increased risk for anxiety disorders

Anxiety disorders found to be more prevalent in youth with CMCs, may also increase adverse disease outcomes

Peer-Reviewed Publication


Washington, DC, May 4, 2020 - Youth who report one of the seven chronic medical conditions (CMCs), including asthma, congenital heart disease, diabetes, epilepsy, inflammatory bowel disease, juvenile idiopathic arthritis, and sickle cell disease, are often diagnosed with an anxiety disorder. A new systematic review in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP), published by Elsevier, examines the prevalence of anxiety disorders and the impact of anxiety on disease-related outcomes for children and adolescents with CMCs.

The research team based in Australia and the Netherlands found the prevalence of anxiety disorders in youth with CMCs was higher than that in the general population. Anxiety may also be associated with adverse disease-related outcomes for children and adolescents with these conditions.

"The issue of 'mental-physical comorbidity' (i.e., meeting diagnostic criteria for least one mental illness and one physical disease) is critical, with the combination of anxiety disorders and physical disease appearing to be particularly prevalent among youth, said lead author Vanessa Cobham, PhD and clinical psychologist at the University of Queensland and Children's Health Queensland's Child and Youth Mental Health Service, Brisbane, Australia.

"Associated with significant implications, the combination of anxiety disorders and a physical disease presents the potential for worsened physical disease outcomes. Health professionals working with children and adolescents with chronic medical conditions should routinely screen for the presence of anxiety disorders in order to provide the best possible care to these youth."

The review based on 53 studies included the examination of prevalence of anxiety disorders and disease-related outcomes across seven different CMCs in children and adolescents with an average age of 18-years or younger.

Twenty-nine studies investigated the occurrence of anxiety disorders and found that more-than-half of the identified studies relied on only one informant (either the youth themselves or parent) in determining whether or not the youth met the criteria for an anxiety disorder. This was seen as the most significant limitation regarding the pervasiveness of an anxiety disorder.

While it is likely these studies underestimate the occurrence of anxiety disorders, the authors did find however that across all CMCs the anxiety prevalence rates were high: affecting approximately 20 percent to 50 percent of youth. In studies that included a healthy control group, rates of an anxiety disorder were substantially higher among patients with all CMCs. Across all CMCs, the rate of anxiety disorder was higher than the global prevalence rate of 6.5 percent as previously reported by Polanczyk and colleagues1.

The remaining 24 studies examined the impact of anxiety on disease-related outcomes. No studies were identified for disease-related outcomes for epilepsy or congenital heart disease, however the authors reported that anxiety was associated with:

  • poorer symptom control, school absenteeism, and higher rates of smoking in youth with asthma;
  • increased disease activity in youth with inflammatory bowel disease;
  • greater pain in youth with juvenile idiopathic arthritis; and
  • longer lengths of hospitalizations in youth with sickle cell disease presenting in vaso-occular crisis.

The most significant and common limitations in relation to the question of the impact of anxiety on disease-related outcomes were the cross-sectional design of most studies and the fact that almost all studies relied on one informant only in assessing both anxiety and disease-related outcomes.

The evidence for youth with diabetes was inconsistent, with some studies reporting a negative impact of anxiety on metabolic control and treatment adherence and other studies reporting a positive association between elevated anxiety and treatment adherence.

While evidence that anxiety is associated with adverse disease-related outcomes in these youth, more longitudinal research is needed to delineate the impact of anxiety on child outcomes, Dr. Cobham and her team concluded. It is recommended that health services routinely assess for anxiety disorders among youth with CMCs. Psychometrically validated anxiety questionnaires (both parent and youth versions) are likely to be a feasible means of screening for anxiety disorders.


Notes for editors
The article is "Systematic Review: Anxiety in Children and Adolescents With Chronic Medical Conditions," by Vanessa E. Cobham, PhD, Anna Hickling, BPsySc(Hons), Hayley Kimball, BPsySc(Hons), Hannah J. Thomas, PhD, James G. Scott, MBBS, PhD, Christel M. Middeldorp, MD, PhD. (

It currently appears on the JAACAP Articles In Press page and will appear in the Journal of the American Academy of Child and Adolescent Psychiatry, volume 59, issue 5 (May 2020), published by Elsevier.

Associate Professor Cobham is a Clinical Psychologist working as a researcher within the School of Psychology, The University of Queensland and as a practicing clinician within Children's Health Queensland, Australia. She is recognized as an international expert in the areas of anxiety and posttraumatic mental health in children and adolescents and has published and presented widely. Her PhD research focused on the role of parents in the etiology and treatment of childhood anxiety disorders.

Copies of this paper are available to credentialed journalists upon request; please contact Mary Billingsley at"> or +1 202 587 9672. Journalists wishing to interview the authors may contact Vanessa Cobham, PhD, School of Psychology, The University of Queensland, at">

1 Polanczyk, G.V., Salum, G.A., Sugaya, L.S., Caye, A., and Rohde, L.A. "Annual research review: a meta-analysis of the worldwide prevalence of mental disorders in children and adolescents." (DOI: 10.1111/jcpp.12381). Journal of Child Psychology and Psychiatry, volume 56 (February 2015), published by John Wiley & Sons.


Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP) is the official publication of the American Academy of Child and Adolescent Psychiatry. JAACAP is the leading journal focusing exclusively on today's psychiatric research and treatment of the child and adolescent. Published twelve times per year, each issue is committed to its mission of advancing the science of pediatric mental health and promoting the care of youth and their families.

The Journal's purpose is to advance research, clinical practice, and theory in child and adolescent psychiatry. It is interested in manuscripts from diverse viewpoints, including genetic, epidemiological, neurobiological, cognitive, behavioral, psychodynamic, social, cultural, and economic. Studies of diagnostic reliability and validity, psychotherapeutic and psychopharmacological treatment efficacy, and mental health services effectiveness are encouraged. The Journal also seeks to promote the well-being of children and families by publishing scholarly papers on such subjects as health policy, legislation, advocacy, culture and society, and service provision as they pertain to the mental health of children and families.

About Elsevier

Elsevier is a global information analytics business that helps scientists and clinicians to find new answers, reshape human knowledge, and tackle the most urgent human crises. For 140 years, we have partnered with the research world to curate and verify scientific knowledge. Today, we're committed to bringing that rigor to a new generation of platforms. Elsevier provides digital solutions and tools in the areas of strategic research management, R&D performance, clinical decision support, and professional education; including ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath. Elsevier publishes over 2,500 digitized journals, including The Lancet and Cell, 39,000 e-book titles and many iconic reference works, including Gray's Anatomy. Elsevier is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers.

Media contact

Mary Billingsley
JAACAP Editorial Office
+1 202 587 9672">

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.