The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association, Acta Pharmaceutica Sinica B (APSB) is a monthly journal, in English, which publishes significant original research articles, rapid communications and high quality reviews of recent advances in all areas of pharmaceutical sciences -- including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Featured papers in this issue are:
Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms by authors Chunfang Xiea, Julien Slagbooma, Laura-Oana Albulescu, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool
(https://doi.org/10.1016/j.apsb.2020.09.005).
This study investigated the small molecule inhibitors varespladib, marimastat and dimercaprol in neutralising coagulopathic Crotalinae (pit vipers) snake venom toxins by using nanofractionation analytics which combines bioassays, liquid chromatography and mass spectrometry in parallel. Results obtained highlight their potential as future snakebite treatments.
Development of 3-mercaptopropyltrimethoxysilane (MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix by authors Yanqiu Gu, Xiao Chen, Yao Wang, Yue Liu, Leyi Zheng, Xiaoqun Li, Rong Wang, Shaozhan Wang, Shengnan Li, Yifeng Chai, Jiacan Su, Yongfang Yuan, Xiaofei Chen
(https://doi.org/10.1016/j.apsb.2020.01.019).
To screen anti-osteoporosis components from Scutellariae Radix, 2D BMMC/CMC-TOFMS analytical system was established and the column life span was significantly prolonged by MPTS modification on silica stationary phase. Tectochrysin was screened out with good anti-osteoporosis activity for the first time.
Interacting with α7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages by authors Etta Y.L. Liu, Yingjie Xia, Xiangpeng Kong, Maggie S.S. Guo, Anna X.D. Yu, Brody Z.Y. Zheng, Shinghung Mak, Miranda L. Xu, Karl W.K. Tsim
(https://doi.org/10.1016/j.apsb.2020.05.005).
AChE regulates cholinergic anti-inflammatory pathway (CAP) in dual processes. First, AChE directly hydrolyzes ACh to promote inflammation via the inhibition of CAP. In parallel, NF-kB bound to ACHE promotor, which triggered the transcription of AChE during inflammation. Second, AChE enhanced the inflammatory responses via the interference with α7 nAChR.
Other articles published in the issue include:
- Special Column: Natural Product Screening
- Editorial
Editorial of Special Column "Natural Product Screening"
Ruin Moaddel, Zhengjin Jiang
https://doi.org/10.1016/j.apsb.2020.10.003
Review articles
Recent advances in screening active components from natural products based on bioaffinity techniques
Xiaofang Hou, Meng Sun, Tao Bao, Xiaoyu Xie, Fen Wei, Sicen Wang
https://doi.org/10.1016/j.jpba.2018.12.009
Nature-derived compounds modulating Wnt/β-catenin pathway: a preventive and therapeutic opportunity in neoplastic diseases
Gianluca Sferrazza, Marco Corti, Gloria Brusotti, Pasquale Pierimarchi, Caterina Temporini, Annalucia Serafino, Enrica Calleri
https://doi.org/10.1016/j.apsb.2019.12.019
Original articles
Rapid identification and isolation of neuraminidase inhibitors from mock strawberry (Duchesnea indica Andr.) based on ligand fishing combined with HR-ESI-Q-TOF-MS
Sifan Luo, Linbo Guo, Caimin Sheng, Yumei Zhao, Ling Chen, Chufang Li, Zhengjin Jiang, Haiyan Tian
https://doi.org/10.1016/j.apsb.2020.04.001
Review articles
Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury
Jin Wang, Hao Zhou
https://doi.org/10.1016/j.apsb.2020.03.004
The role of lysosome in regulated necrosis
Aqu Alu, Xuejiao Han, Xuelei Ma, Min Wu, Yuquan Wei, Xiawei Wei
https://doi.org/10.1016/j.apsb.2020.07.003
Modulation of protein fate decision by small molecules: targeting molecular chaperone machinery
Lei Wang, Xiaoli Xu, Zhengyu Jiang, Qidong Youb
https://doi.org/10.1016/j.apsb.2020.01.018
Original articles
Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1
Mingxing Hu, Weilin Zhou, Yijie Wang, Dongping Yao, Tinghong Ye, Yuqin Yao, Bin Chen, Gongping Liu, Xifei Yang, Wei Wang, Yongmei Xie
https://doi.org/10.1016/j.apsb.2020.02.010
Structure, property, biogenesis, and activity of diterpenoid alkaloids containing a sulfonic acid group from Aconitum carmichaelii
Qinglan Guo, Huan Xi, Yuzhuo Wu, Shuai Shao, Chengbo Xu, Tiantai Zhang, Jiangong Shi
https://doi.org/10.1016/j.apsb.2020.01.013
Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases
Yuge Zhao, Yuting Yang, Jiaxin Zhang, Rong Wang, Biyun Cheng, Dipika Kalambhe, Yingshu Wang, Zeyun Gu, Dongying Chen, Bing Wang Yongzhuo Huang
https://doi.org/10.1016/j.apsb.2020.07.019
Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS
Rong Guo, Yang Long, Zhengze Lu, Miao Deng, Penghui He, Man Li, Qin He
https://doi.org/10.1016/j.apsb.2019.06.008
The large single-copy (LSC) region functions as a highly effective and efficient molecular marker for accurate authentication of medicinal Dendrobium species
Ludan Li, Yu Jiang, Yuanyuan Liu, Zhitao Niu, Qingyun Xue, Wei Liu, Xiaoyu Ding
https://doi.org/10.1016/j.apsb.2020.01.012
Short communication
Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with particular reference to P-glycoprotein
Tingting Wang, Yingjie Guo, Yang He, Tianming Ren, Lei Yin, John Paul Fawcett, Jingkai Gu, Huimin Sun
https://doi.org/10.1016/j.apsb.2020.02.001
Letter to the Editor
Increased plasma ACE2 concentration does not mean increased risk of SARS-CoV-2 infection and increased fatality rate of COVID-19
Xueting Li, Ying Liu, Juanjuan Song, Jiuchang Zhong
https://doi.org/10.1016/j.apsb.2020.09.003
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(https://www.editorialmanager.com/apsb/default.aspx).
CiteScore: 10.5
Impact Factor: 7.097
5-Year Impact Factor: 7.865
Source Normalized Impact per Paper (SNIP): 2.210
SCImago Journal Rank (SJR): 1.792
ISSN 2211-3835