A Colorado State University team of single-molecule biophysicists and biochemists have shed light on a long-obscured cellular process: a mammalian cell membrane's relationship with a scaffolding underneath it, the cortical actin cytoskeleton. For the first time, the CSU team has made real-time observations of this cytoskeleton acting as a barrier that organizes proteins on the cell's surface, effectively playing traffic cop on the cell's membrane activities.
Northwestern Medicine scientists have found a molecule that stops the growth of an aggressive pediatric brain tumor. The tumor is always fatal and primarily strikes children under 10 years old. Every other attempted therapy has failed.
A University of Cincinnati (UC) researcher who has developed an immunotherapy to help reverse cocaine addiction that's been successful in animal models says he hopes to have it in clinical trials in human volunteers within a year.
The skin cells of four adults with schizophrenia have provided an unprecedented 'window' into how the disease began while they were still in the womb, according to a recent paper in Schizophrenia Research.
The mystery of what controls the range of developmental clocks in mammals -- from 22 months for an elephant to 12 days for a opossum -- may lie in the strict time-keeping of pluripotent stem cells for each unique species.
The Karmanos Cancer Institute and Wayne State University School of Medicine will launch the nation's largest study of African-American cancer survivors to better understand disproportionately high incidence and mortality from cancer and its impact on this specific patient population.
Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new regulator of the innate immune response -- the immediate, natural immune response to foreign invaders. The study, published recently in Nature Microbiology, suggests that therapeutics that modulate the regulator -- an immune checkpoint--may represent the next generation of antiviral drugs, vaccine adjuvants, cancer immunotherapies, and treatments for autoimmune disease.
A new bioinspired process combines top-down and bottom-up assembly to turn silk protein into materials that are easily programmable at the nano-, micro- and macro-scales; ultralight; and robust. Structures made included a web of silk nano fibers able to sustain a load 4,000 times its own weight.
Genes from a common bacterium can be harnessed to sterilize male insects, a tool that can potentially control populations of both disease-bearing mosquitoes and agricultural pests, researchers at Yale University and Vanderbilt University report in related studies published Feb. 27 in two Nature journals.
Discovery of the genes the insect parasite Wolbachia uses to control its hosts' reproduction provides a powerful new tool for enhancing biological control efforts for mosquito-borne diseases like dengue, Zika and malaria.