New research from the University of Illinois at Chicago suggests that the lung microbiome plays a significant role in asthma severity and response to treatment.
Figuring out how accurate replication works at the level of individual molecules and atoms is one of the great achievements of modern science. The journey of investigators is not yet done, however. A major unsolved part of the puzzle is understanding how the entire process of copying the genome begins. In new research, insight into how the two stands of the double helix separate in the earliest stages of replication is becoming clear.
A University of Colorado Cancer Center study published today in the journal Molecular Cancer Therapeutics finds a genetic change called ALK-fusion in a patient sample of a melanoma subtype called mucosal melanoma. When researchers treated a tumor grown from this sample with the drugs crizotinib and ceritinib -- both FDA approved to treat ALK-positive lung cancer -- the tumor responded dramatically.
An Emory/Yonsei team developed a new method for generating endothelial cells, which make up the lining of blood vessels, from human iPSCs. When endothelial cells are surrounded by a supportive gel and implanted into mice with damaged blood vessels, they become part of the animals' blood vessels, surviving for more than 10 months.
Northwestern Medicine scientists have revealed how oxidative stress explains a common herbicide's link to risk of Parkinson's disease.
People who exhibit even a few depressive symptoms before a major life stressor, such as a disaster, may experience an increase in inflammation -- a major risk factor for heart disease and other negative health conditions -- after the event.
A team of researchers from Case Western Reserve University School of Medicine have discovered how uncontrolled vitamin A metabolism in the gut can cause harmful inflammation. The discovery links diet to inflammatory diseases, like Crohn's disease and inflammatory bowel syndromes, and could inform nutritional interventions.
With $3.8 million in support from the National Institute on Aging, University of California, Irvine, neurobiologists are working to identify the early indicators of dementia in older adults as disease-related brain plaques accumulate but before symptoms can be observed.
Researchers found that in B cell tumors, mutated overactive versions of the Notch protein directly drive the expression of the Myc gene and many other genes that participate in B cell signaling pathways. Myc is a critical gene in governing cell proliferation and survival.
Researchers have demonstrated how to decode what the human brain is seeing by using artificial intelligence to interpret fMRI scans from people watching videos, representing a sort of mind-reading technology.