Mount Sinai Scientists developed a novel way to barcode and track different CRISPRs by utilizing synthetic proteins built from combinations of smaller proteins, called epitopes. By being able to mark each CRISPR with a unique identifier, the protein barcodes, or Pro-Codes for short, enable hundreds of CRISPRs to be used together to knockout a multitude of genes.
In new studies conducted at UC San Francisco, a novel oxygen-delivery therapeutic restored the function of oxygen-starved heart tissue in an animal model of global hypoxia. Unlike its experimental predecessors, the new drug does not appear to cause systemic side effects or overcorrect with excessive blood oxygenation, which can itself be toxic. Instead, the new drug delivers its precious oxygen cargo only to the tissues that need it most.
A study led by the University of Washington is the first large-scale trial of hundreds of PTSD patients, including veterans and survivors of sexual assault, to measure whether patient preference in the course of treatment impacts the effectiveness of a type of cognitive behavioral therapy and use of selective serotonin reuptake inhibitors, a type of antidepressant often prescribed for PTSD.
A new Florida State University College of Medicine study in mice produced results that suggest nicotine exposure in men could lead to cognitive deficits in their children and grandchildren. Further studies will be required to know if the same outcomes seen in mice would apply to humans.
Adding highly refined fiber to processed foods could have negative effects on human health, such as promoting liver cancer, according to a new study by researchers at Georgia State University and the University of Toledo.
While it is widely shown that possessing the ApoE4 gene is the major genetic risk factor of Alzheimer's disease (AD), not all ApoE4 carriers develop AD. For the first time, researchers at Boston University School of Medicine (BUSM) have shown that ApoE4 linked with chronic inflammation dramatically increases the risk for AD. This can be detected by sequential measurements of C-reactive protein, a common clinical test which can be could be done routinely in a clinical setting.
Neuroscientists have found a brain region that appears to be strongly connected to food preference decisions, like what to choose from a buffet line or potluck table.
Despite a policy change to provide free abortion services for women traveling from Northern Ireland to clinics in Great Britain, Northern Irish women still experience multiple barriers accessing care. The study also found that some women preferred to use medication from online telemedicine services to self-manage their own abortions at home, but that the experience is dominated by fear and isolation due to the risk of prosecution.
E-cigarette brand JUUL's Twitter handle is attracting adolescents to the point that at least a quarter of its followers appear to be under age 18. Many of these minors -- to whom it is illegal to sell nicotine-delivery products -- are retweeting JUUL's messages, amplifying its advertisements.
The more that families understand the end-of-life treatment preferences expressed by adolescents living with human immunodeficiency virus (HIV), the less likely these youth are to suffer HIV-related symptoms compared with youths whose families do not understand their end-of-life care goals, according to a single-blinded, randomized study published online Oct. 19, 2018, in Pediatrics.