Formation of new blood vessels, a process also known as angiogenesis, is one of the major clinical challenges in wound healing and tissue implants. To address this issue, researchers from Texas A&M University have developed a clay-based platform to deliver therapeutic proteins to the body to assist with the formation of blood vessels.
In a pair of new modeling studies, researchers at University of California San Diego School of Medicine, with international colleagues, examined how policy reform in terms of drug decriminalization (in Mexico) and access to drug treatment (in Russia) might affect two regions hard hit by the HIV pandemic: Tijuana, Mexico and the Russian cities of Omsk and Ekaterinburg.
A few little cells that are different from the rest can have a big effect. For example, individual cancer cells may be resistant to a specific chemotherapy -- causing a relapse in a patient who would otherwise be cured. In the journal Angewandte Chemie, scientists have now introduced a microfluidics-based chip for the manipulation and subsequent nucleic-acid analysis of individual cells. The technique uses local electric fields to highly efficiently 'trap' the cells (dielectrophoresis).
When enrolled in a cancer clinical trial, the differences in survival rates between rural and urban patients are significantly reduced, SWOG study results show.
A team of investigators led by Beth Israel Deaconess Medical Center (BIDMC) medical oncologist Rupal Bhatt, M.D., Ph.D., has demonstrated that a molecule called KIM-1, a protein present in the blood of some patients with renal cell carcinoma is present at elevated levels at the time of diagnosis, can also serve as a tool to predict the disease's onset up to five years prior to diagnosis.
In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell's internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. Such targeted editing could one day be useful for treating genetic diseases caused by mutations in the genome, such as Duchenne's muscular dystrophy, Huntington's disease or some cancers.
A team of researchers from Penn Medicine has developed the first mouse model with an IPF-associated mutation, which induces scarring and other damage similar to what is observed in humans suffering from the condition.
A new study focusing on the environment inside cancer cells may lead to new targeted treatment strategies. Moffitt Cancer Center researchers, in collaboration with colleagues from the University of Maryland and the Institute for Research in Biomedicine Barcelona, suggest that lowering the pH inside cancer cells to make it more acidic can slow down the growth and spread of the disease, and possibly provide new options for treatment. Their results were published in Nature Communications.
Scientists at Scripps Research have solved the structure of a key protein that senses when our cells swell.
Autoimmunity plays a role in the development of chronic obstructive pulmonary disease (COPD), according to a study led by Georgia State University and Vanderbilt University Medical Center that analyzed human genome information stored in Vanderbilt's DNA biobank.