In the first study to comprehensively evaluate research priorities for patient safety in pediatrics, St. Jude Children's Research Hospital researchers and collaborators from other children's hospitals outlined 24 research priorities for improving pediatric patient care and safety. Topics identified as most important included how organizations use high reliability principles, create and improve their safety culture, communicate about patient care, and use early-warning systems to proactively prevent and detect patient decline.
For children--whose tiny bodies are still growing--chemotherapy and radiation treatments can cause lifelong damage. Now, scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have reported that a targeted therapy that blocks a protein called LSD1 was able to shrink tumors in mice with a form of pediatric brain cancer known as medulloblastoma. LSD1 inhibitors are currently under evaluation in clinical trials for other cancers. The study was published in Nature Communications.
Adolescents and young adults living in states with more liberal policies reported higher average rates of past-year cannabis use than those in states with more conservative policies. However, the rates of cannabis use disorder -- abuse or dependence on the drug -- were significantly lower in states with more liberal policies compared to states with more conservative policies. The study is one of the first to assess the relationship between policy liberalism and health outcomes, and specifically cannabis use-related outcomes.
Growing muscle tissue on grooved platforms helps neurons more effectively integrate with the muscle, a requirement for engineering muscle in the lab that responds and functions like muscle in the body, University of Illinois researchers found in a new study. Such engineered muscle with integrated nerves has applications in reconstructive and rehabilitative medicine, as well as for engineered biological machines or robots.
A diagnosis of prediabetes should be a warning for people to make lifestyle changes to prevent both full-blown diabetes and cardiovascular disease (CVD), according to scientists at Wake Forest School of Medicine.
A new study by Columbia researchers suggests aspirin may lower stroke risk among middle-aged women with a history of preeclampsia.
Prions can infect both humans and animals, causing Creutzfeldt-Jakob disease (CJD) in humans, mad cow disease in cattle, and chronic wasting disease in elk and deer. The infectious, misfolded protein particles often go undetected as they destroy brain tissue, causing memory loss, mobility issues, and ultimately death. Preclinical detection of prions has proven difficult, but new research suggests skin samples hold early signs of prion disease that precede neurologic symptoms.
Researchers have demonstrated for the first time how two molecular strategies can safeguard CRISPR gene-drive experiments in the lab, according to a study published today in eLife.
Researchers at University of California San Diego School of Medicine found that a diet low in free sugars (those added to foods and beverages and occurring naturally in fruit juices) resulted in significant improvement in nonalcoholic fatty liver disease (NAFLD) in adolescent boys.
Researchers at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, and colleagues, discovered a promising direction toward understanding the development of necrotizing enterocolitis (NEC), a devastating intestinal disease commonly affecting premature infants, in order to treat it.