Tufts Medical Center (Tufts MC) joins an elite group of institutions selected to lead national clinical trials in the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) Network, a new initiative of the National Institutes of Health (NIH) to advance critical emergency medicine research. The SIREN Network is five-year NIH cooperative award that brings together 15 'Hub' institutions and their local 'spoke' sites to provide a national infrastructure for conducting large multi-site clinical trials.
Case Western Reserve University School of Medicine, in partnership with the Case Comprehensive Cancer Center, was awarded a five-year grant, totaling $2.5 million to engage underrepresented minorities in Cleveland-area schools in cancer research.
In a new study published in Science Immunology, researchers from Brigham and Women's Hospital and Monash University in Australia reveal new insights into the basis for T cell receptor (TCR) autoreactivity to self-phospholipids, with implications for autoimmune diseases.
Environmental health scientist Alicia Timme-Laragy at the University of Massachusetts Amherst recently received a $1.9 million grant from the National Institute of Environmental Health Sciences to study the health effects of two environmental pollutants, perfluoro-octanesulfonic acid (PFOS) and its recent replacement chemical, perfluoro-butanesulfonic (PFBS).
"There is confusion about whether e-cigarettes are 'safer' than cigarettes because the potential adverse effects of e-cigarettes are only beginning to be studied," said Kesimer, who is also a member of the UNC Marsico Lung Institute. "This study looked at possible biomarkers of harm in the lungs. And our results suggest that in some ways using e-cigarettes could be just as bad as smoking cigarettes."
A new vaccine under development provoked an immune response to 72 forms of the bacteria that's responsible for pneumonia, sepsis and meningitis. That's up from the 23 forms of bacteria covered by current immunizations. The new vaccine, which represents the 'most comprehensive' coverage of pneumococcal disease to date, could greatly reduce the number of deaths from the disease.
E-cigarettes appear to trigger unique immune responses as well as the same ones that cigarettes trigger that can lead to lung disease, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
A protein shaped like a 'Y' makes scientists do a double-take and may change the way they think about a protein sometimes implicated in glaucoma. The Y is a centerpiece in myocilin, binding four other components nicknamed propellers together like balloons on strings.
University of California San Diego researchers have developed the first 3-D spatial visualization tool for mapping 'omics' data onto whole organs. The tool helps researchers and clinicians understand the effects of chemicals, such as microbial metabolites and medications, on a diseased organ in the context of microbes that also inhabit the region. The work could advance targeted drug delivery for cystic fibrosis and other conditions where medications are unable to penetrate.
A yeast protein that evolved from scratch can fold into a compact three-dimensional shape -- contrary to the general understanding of young proteins. Recent evidence suggests new genes can arise from the non-coding sections, or 'junk,' DNA and that those new genes could code for brand-new proteins. Scientists thought such newly evolved proteins were works-in-progress that could not fold into complex shapes the way more ancient proteins do.