Detailed study of how domains within the Cas9 protein move when the molecule binds to DNA has allowed UC Berkeley, Harvard and Massachusettes General Hospital scientists to locate the protein that monitors the fidelity of binding between the Cas9 single-guide RNA and its DNA target. The researchers then tweaked this domain to boost specificity, creating the highest fidelity Cas9 protein to date.
Some of the world's most beloved plants -- coffee, bananas, potatoes, chrysanthemums and roses, to name a few -- could be made even better, but the complexity of their chromosomes either stumps or stifles scientists who study them. With a $47,000 grant from the U.S. Department of Agriculture-National Institute of Food and Agriculture, about 40 researchers will convene in San Diego Jan. 11-12 to begin collaborating on polyploid studies.
The answer to the question of why some organisms can regenerate major body parts while others, such as humans, cannot may lie with the body's innate immune system, according to a new study of heart regeneration in the Mexican salamander by James Godwin, Ph.D., of the MDI Biological Laboratory. Godwin found that formation of new heart muscle tissue after a heart attack is dependent on the presence of macrophages, a type of white blood cell.
A new five-year grant totaling $5,382,423 to Jackson Laboratory (JAX) Assistant Professor Catherine Kaczorowski will fund research to explore why some people with a family history of Alzheimer's disease, and even brain changes associated with the disease, nevertheless manage to maintain their cognitive capabilities
A team of engineers and clinicians at Rochester Institute of Technology and the University of Rochester Medical Center received a grant from the National Institutes of Health to develop a non-contact, video recording technology to detect the presence of atrial fibrillation.
As the embryonic brain develops, a complex cascade of cellular events occur, starting with progenitors -- the originating cells that generate neurons and spur proper cortex development. If this cascade malfunctions then the brain can develop abnormally. Eva Anton's lab at UNC has shown how the deletion of the protein APC in progenitor leads to massive disruption of brain development and the Wnt protein pathway, which previously was linked to genes associated with autism.
Communication breakdowns between care facilities can pave the way for outbreaks of infection, according to research on the spread of an extensively drug-resistant bacterium.
A new study from UC Davis shows that the so-called 'love hormone' oxytocin can intensify negative as well as positive experiences.
Researchers at Joslin Diabetes Center have identified an unexpected natural protective factor against chronic inflammation that drives cardiovascular disease in type 2 diabetes.
Van Andel Research Institute scientist Scott Rothbart, Ph.D., has been awarded a five-year, $2.375 million Maximizing Investigators' Research Award from the National Institute of General Medical Sciences of the National Institutes of Health that will fuel in-depth, multidisciplinary studies into the epigenetic control mechanisms that regulate the genetic code.