Investigators from Children's Hospital Los Angeles and 37 other Children's Oncology Group hospitals in the US and Canada have determined that sodium thiosulfate prevents cisplatin-induced hearing loss in children and adolescents with cancer. Results of this randomized, controlled, phase 3 study, called ACCL0431, have been published in the early online edition of Lancet Oncology.
Working with human immune cells in the laboratory, Johns Hopkins researchers report they have identified a critical cellular 'off' switch for the inflammatory immune response that contributes to lung-constricting asthma attacks. The switch, they say, is composed of regulatory proteins that control an immune signaling pathway in cells.
Scientists hoping to see molecules that control brain activity have devised a probe that lets them image such molecules without using chemical or radioactive labels. The sensors consist of proteins that detect a particular target, which causes them to dilate blood vessels, producing a change in blood flow that can be imaged with magnetic resonance imaging (MRI) or other techniques.
Hospitals in which the administration of epinephrine to patients whose hearts have stopped is delayed beyond five minutes have significantly lower survival rates of those patients, a new study led by a cardiologist at UT Southwestern Medical Center finds.
Study provides early evidence that a panel of microRNA may be used in the future as a biomarker for several types of cancer.
MUSC Psychologist Justin Gass believes repeated alcohol exposure stregthens the connections between neurons in the brain responsible for storing traumatic memories.
New research finds that small regions of the brain cycle in and out of sleep, even when awake. The cycles shift toward 'awake' when that part of the brain pays attention to a task.
An Indiana University nursing researcher has been awarded $1.1 million to study the ethical complexities of involving adolescents ages 14-17 at high risk for HIV in biomedical prevention trials.
New research findings published in the Journal of Leukocyte Biology (http://www.jleukbio.org), suggest that treating the white blood cells of sepsis patients with antibodies that block programmed cell death-1 (PD-1) and programmed cell death ligand (PD-L1) molecules may restore their function and ultimately their ability to eradicate deadly bacteria.
A new scientific discovery may provide a future avenue for treatment and prevention of Alzheimer's disease. A study published Nov. 28 in the journal JAMA Neurology examined aquaporin-4, a type of membrane protein in the brain. Using brains donated for scientific research, researchers at OHSU discovered a correlation between the prevalence of aquaporin-4 among older people who did not suffer from Alzheimer's as compared to those who had the disease.