Researchers at the Medical University of South Carolina Hollings Cancer Center have discovered a mechanism that confers resistance to drugs used to treat certain types of acute myeloid leukemia. Targeting this pathway with a novel lipid-based therapeutic showed efficacy in a preclinical model of AML. These findings were reported in an article published in the Oct. 13, 2016 issue of Blood.
A study of US Hispanics with diabetes mellitus showed a link between impaired glucose regulation and adverse measures of cardiac function and structure. Researchers extended previous knowledge regarding the concept of 'diabetic cardiomyopathy, by also observing that these relationships emerged early and before the full onset of diabetes mellitus.
A $450,000 grant from the National Institutes of Health will help biology professor Colleen Novak, Ph.D., from Kent State University's College of Arts and Sciences better understand how the body allocates energy and burns fat.
Why do more women than men get Alzheimer's disease? In their quest to find the answer, neuroscientist Roberta Diaz Brinton, Ph.D., and her colleagues in the Center for Innovation in Brain Science at the University of Arizona Health Sciences, have been awarded a $10.3 million five-year Program Project Grant from the National Institute on Aging.
Engineers and biologists have for the first time revealed the mechanics of how bacteria build up slimy masses called biofilms, cell by cell. When encased in biofilms in the human body, bacteria are a thousand times less susceptible to antibiotics, making certain infections, such as pneumonia, difficult to treat and potentially lethal.
Researchers at the Beckman Institute for Advanced Science and Technology at the University of Illinois and the Southern Illinois University School of Medicine in Springfield have collaborated on creating a comprehensive, interactive rat brain atlas.
In a discovery that advances the understanding of how marijuana works in the human body, an international group of scientists, including those from the Florida campus of The Scripps Research Institute (TSRI), have for the first time created a three-dimensional atomic-level image of the molecular structure activated by tetrahydrocannabinol (THC), the active chemical in marijuana.
The common laboratory frog Xenopus laevis has puzzled researchers because it has twice the normal number of genes. A newly published genome sequence shows why: between 15 and 20 million years ago, two different species interbred and produced a hybrid, which then mated with its parent species to eventually form a new organism with a doubled genome. The frog has since adapted to the excess by losing or disabling many of these genes.
Having strong social connections has many benefits, from splitting the tab on a pizza to having someone with whom to binge watch Netflix. But for rhesus macaque monkeys at the California National Primate Research Center (CNPRC) at UC Davis, uncertainty about where they rank in their social order may mean the difference between being healthy or not.
By studying Andean bird species adapted to high altitudes, University of Nebraska-Lincoln biologist Jay Storz and colleagues found that even if natural selection produces similar beneficial traits in different species, evolutionary changes at the molecular level are idiosyncratic and less predictable.