In a new study, a team from the University of Pennsylvania describes how X chromosome inactivation is regulated in the immune system's B cells as they develop in bone marrow and when they encounter antigens.
Breast cancer cells recycle ammonia, a waste byproduct of cell metabolism, and use it as a source of nitrogen to fuel tumor growth, report scientists from Harvard Medical School. The insights shed light on the biological role of ammonia in cancer and may inform the design of new therapeutic strategies to slow tumor growth.
Modeling the interplay between neurons and astrocytes derived from children with Autism Spectrum Disorder (ASD), researchers at University of California San Diego School of Medicine, with colleagues in Brazil, say innate inflammation in the latter appears to contribute to neuronal dysfunction in at least some forms of the disease.
Investigator at Children's Hospital Los Angeles is awarded $1.7 million by the NIH to study the impact of prematurity on brain development. The goal of the study is to develop biomarkers for early detection of risk for cognitive problems and behavioral disorders in premature infants. The expected findings could improve physicians' ability to predict adverse outcomes and design early intervention programs to encourage healthy neurological development for newborns at risk.
Imagine being able to quickly and accurately screen for diseases or chemical contaminants in a tiny drop of blood. Berkeley Lab scientist Daojing Wang and others have developed a multinozzle emitter array (MEA), a silicon chip that can dramatically shorten the time it takes to identify proteins, peptides, and other molecular components within small volumes of biological samples. This patented technology is now being commercialized by Newomics Inc., a company Wang launched to further develop the product and build a platform for personalized health care.
Melanoma, a cancer of skin pigment cells called melanocytes, will strike an estimated 87,110 people in the US in 2017, according to the Centers for Disease Control and Prevention. A fraction of those melanomas come from pre-existing moles, but the majority of them come from sources unknown -- until now.
University of Pittsburgh and UPMC researchers reviewed existing evidence and found that heart failure patients receive significantly less palliative care than patients with other illnesses, despite evidence that such care improves symptom management and quality of life.
A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies potential new therapeutic avenues for patients with Alagille syndrome, a rare genetic disorder caused by mutations primarily in the JAGGED1 gene.
Scientists at the Massachusetts General Hospital, in collaboration with colleagues at the University California, San Diego, have characterized a new class of drugs as potential therapeutics for Alzheimer's disease and discovered a piece in the puzzle of how they would work.
A new study on two specially bred strains of mice has illuminated how abnormal addition of the chemical phosphate to a specific heart muscle protein may sabotage the way the protein behaves in a cell, and may damage the way the heart pumps blood around the body.