A new study has identified two genes associated with hyperemesis gravidarum, whose cause has not been determined in previous studies. The genes, known as GDF15 and IGFBP7, are both involved in the development of the placenta and play important roles in early pregnancy and appetite regulation.
Mexican cavefish have insulin resistance, a hallmark of many human metabolic disorders and a precursor to type 2 diabetes that can lead to an overworked pancreas, excess fat storage and chronically elevated blood sugar. Despite dysregulated blood sugar, the fish don't suffer the same health consequences people do. Study offers a fresh opportunity to understand how animals thrive with traits that sicken humans and could point the way to new interventions for disease.
Researchers at Columbia University Irving Medical Center found that obesity increases the liver's production of an enzyme that triggers inflammation in belly fat. Targeting the enzyme in the liver could present a new way to treat type 2 diabetes.
A new study by Dana-Farber Cancer Institute scientists suggests it may be possible to prevent tumors from recurring and to eradicate metastatic growths by implanting a gel containing immunotherapy during surgical removal of a tumor.
Diets rich in mono-unsaturated fats from plants may lower the risk of death from heart disease and other causes. The largest reductions in the risk of death were found when healthy fats from plant sources replaced saturated fats, trans fats and refined carbohydrates.
Among people who routinely eat meat, chicken and fish, those who grill, broil or roast these foods at high temperatures may be more likely to develop high blood pressure.
The nation's overall cardiovascular health worsened from 1988 to 2014, with disparities among racial and ethnic groups dropping slightly. But the reduction in disparities was due to worsening health among whites -- not improvements among African-Americans and Mexican-Americans.
New research from scientists at the La Jolla Institute shows how a diet high in fat and cholesterol depletes the ranks of artery-protecting immune cells, turning them into promoters of inflammation, which exacerbate atherosclerotic plaque buildup that occurs in cardiovascular disease. The team has also found that high density lipoproteins (HDL)--more commonly known as "good cholesterol"--counteract this process, helping the protective immune cells maintain their identity and keep arteries clear.
VCU Massey Cancer Center researchers have identified two genes that are responsible for governing the replication of the Epstein-Barr virus, an infection that drives the growth of several types of cancer. The discovery could lead to the development of novel therapies for virus-associated diseases including stomach cancer and lymphomas.
A medicine that slows balding and stimulates hair growth also may make stiff vessels more stretchy and improve blood flow to vital organs like the brain, according to an experimental model study.