Drug addiction may not require a habitual relationship with a substance, suggests findings from a new model of cocaine administration in rats that better captures the human experience of obtaining and using drugs. The research, published in JNeurosci, represents a step towards a translational animal model of addiction that challenges widely held views about drug users.
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have developed new opioid pain relievers that reduce pain on par with morphine but do not slow or stop breathing -- the cause of opiate overdose.
A new study concludes that two of the top medications available for outpatient, office-based treatment, once initiated, are equally safe and effective in curtailing opioid use, relapse, treatment drop-out and overdose.
The reward center of the brain is much more attuned to the pleasurable effects of alcohol when estrogen levels are elevated, an effect that may underlie the development of addiction in women, according to a study on mice at the University of Illinois at Chicago.
A potential new antidepressant and antianxiety treatment with a unique mechanism of action has been developed by scientists at the University of Bath.
Alcohol-fueled parties might be seen as a rite of passage for many high school students, but they have an unexpected impact: binge-drinking behavior as teenagers can lead to problems with alcohol and other drug dependence later on in life.
Bioengineers at the University of Pittsburgh have developed a new method of using synthetic DNA called 'aptamers' to view the effect of cocaine on the brain in real-time with a much higher resolution than other techniques. Dr. Tracy Cui is principal investigator for a two-year, $421,185 new study titled "Dual Polymer Coatings for High Fidelity and Stable In Vivo Cocaine Sensing From MEAs." Funding comes from a R21 Exploratory/Development grant from the National Institutes of Health National Institute on Drug Abuse.
A large portion of patients taking prescription drugs that could affect driving may not be aware they could potentially be driving impaired, according to research in the November issue of the Journal of Studies on Alcohol and Drugs.
Depression is on the rise in the United States. From 2005 to 2015, depression rose significantly among Americans age 12 and older with the most rapid increases seen in young people. This is the first study to identify trends in depression by gender, income, and education over the past decade.
Female medical interns are more likely to suffer from symptoms of depression than their male counterparts, and the conflict between work and family responsibilities is a factor in that gender difference about a third of the time. That's a key finding of a study published today in the Journal of the American Medical Association - Internal Medicine.