Tony Wynshaw-Boris, M.D., Ph.D., has received two five-year grants totaling more than $5 million from the National Institute of Mental Health of the NIH to uncover links between abnormal embryonic brain development and autism.
A new study conducted by investigators from Brigham and Women's Hospital (BWH) in collaboration with investigators in the five Nordic countries leverages data from multiple large cohorts to define and quantify what, if any, increased risk may be posed by taking the most commonly used ADHD medications. The team found that one medication, methylphenidate, increased risk of heart defects by a small amount while another medication, amphetamines, did not.
A new study linking higher levels of air pollution to increased teenage delinquency is a reminder of the importance of clean air and the need for more foliage in urban spaces. The study suggests ambient air pollution may increase delinquent behavior among 9- to 18-year-olds in urban neighborhoods in Greater Los Angeles. The insidious effects are compounded by poor parent-child relationships and parental mental and social distress, said Keck School of Medicine of USC researchers.
Bipolar disorder may involve accelerated epigenetic aging, which could explain why persons with the disorder are more likely to have -- and die from -- age-related diseases, according to researchers from McGovern Medical School at UTHealth in Houston.
Researchers at the University of Illinois at Chicago have found that a brief test that can be performed in the office can help determine whether an antidepressant or a form of talk therapy, called cognitive behavioral therapy or CBT, would be better at relieving symptoms of anxiety in individual patients.
Racial differences in parents' reports of concerns about their child's development to healthcare providers may contribute to delayed diagnosis of autism spectrum disorder (ASD) in black children, according to a study led by Georgia State University.
Houston Methodist is making mini brains from human stem cells, putting researchers on a fast track to repair the nervous system after injury or disease of the brain and spinal cord. Researchers have developed a new system to reduce the time it takes to grow these brain models, which will give them the ability to screen drugs and study what's behind disease-causing mutations more quickly. The findings appear Dec. 12 in Stem Cell Reports.
DNA sequences between mitochondria within a single cell are vastly different, found researchers in the Perelman School of Medicine at the University of Pennsylvania. This knowledge will help to better illuminate the underlying mechanisms of many disorders that start with accumulated mutations in individual mitochondria and provide clues about how patients might respond to specific therapies.
Fasudil, a drug that stimulates neuron pruning, can nudge mice away from habit-driven behaviors when combined with retraining. A potential tool for facilitating the treatment of drug abuse and preventing relapse.
The most dramatic divergence between humans and other primates can be found in the brain, the primary organ that gives our species its identity. However, all regions of the human brain have molecular signatures very similar to those of our primate relatives, yet some regions contain distinctly human patterns of gene activity that mark the brain's evolution and may contribute to our cognitive abilities, a new Yale-led study has found.