A misunderstanding of how the certain parts of the brain function has hampered the creation of pharmaceuticals to effectively address fear and anxiety disorders, a pair of researchers has concluded.
Researchers at the Institute for the Developing Mind at Children's Hospital Los Angeles have analyzed current gene-disease findings to understand why people with neurodevelopmental and mental illness often have physical disorders.
The Johns Hopkins University School of Medicine and the Salk Institute for Biological Studies will co-lead a $15.4 million effort to develop new systems for quickly screening libraries of drugs for potential effectiveness against schizophrenia and bipolar disorder, the National Institute of Mental Health has announced. The consortium, which includes four academic or nonprofit institutions and two industry partners, will be led by Hongjun Song of Johns Hopkins and Rusty Gage of Salk.
To remember events in the order they occur, the brain's neurons function in a coordinated way that is akin to a symphony, a team of NYU scientists has found. Their findings offer new insights into how we recall information and point to factors that may disrupt certain types of memories.
Research led by SUNY Downstate Medical Center shows that, at the onset of puberty, the emergence of a novel inhibitory brain receptor, α4βδ (alpha four beta delta), reduces seizure-like activity in a mouse model of epilepsy.
Johns Hopkins neuroscientists believe they have figured out how some rats solve certain navigational problems. If there's a 'reward' at the end of the trip, like the chocolatey drink used in this study, specialized neurons in the hippocampus of the brain 'replay' the route taken to get it, but backward. And the greater the reward, the more often the rats' brains replay it.
Cancer researchers have long observed the value of treating patients with combinations of anti-cancer drugs that work better than single drug treatments. Now, in a new study using laboratory-grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.
Thanks to new funding from the National Institute on Drug Abuse, researchers at the Lewis Katz School of Medicine at Temple University will explore the effects of the combination of tobacco smoke and opiates on the tissue damage that occurs in many patients infected with HIV.
While even the best wines eventually peak and turn to vinegar, a new study by researchers at University of California, San Diego School of Medicine suggests a paradoxical trend in the mental health of aging adults: they seem to consistently get better over time.
Researchers have developed a new opioid drug candidate that blocks pain without triggering the dangerous side effects of current prescription painkillers. Their secret? Starting from scratch -- with computational techniques that let them explore more than four trillion different chemical interactions.