Analysis of large data sets from post-mortem brain samples of people with and without Alzheimer's disease has revealed new evidence linking viruses to Alzheimer's clinical traits and genetic factors. Researchers funded by the National Institute on Aging (NIA), part of the National Institutes of Health, made the discovery by harnessing data from brain banks and cohort studies participating in the Accelerating Medicines Partnership-Alzheimer's Disease (AMP-AD) consortium.
Children as young as 3-years-old can be diagnosed with clinical depression. Although young children are sometimes prescribed antidepressants, a psychotherapeutic intervention is needed. Researchers adapted Parent-Child Interaction Therapy (PCIT), (a validated treatment for disruptive behavioral disorders in children), by adding new emotional development content. PCIT-ED treatment resulted in significant improvements in depression for both children and their parents, suggesting PCIT-ED as a powerful and low-risk approach to the treatment of preschool depression.
A National Institutes of Health-funded study found that treatment of opioid use disorder with either methadone or buprenorphine following a nonfatal opioid overdose is associated with significant reductions in opioid related mortality. The research, published today in the Annals of Internal Medicine, was co-funded by the National Institute on Drug Abuse (NIDA) and the National Center for Advancing Translational Sciences, both parts of NIH.
The National Institute of Allergy and Infectious Diseases (NIAID), part of NIH, has launched a clinical trial of an investigational vaccine designed to protect against respiratory syncytial virus (RSV). The Phase 1 study will enroll a small group of healthy adult volunteers to examine the safety of an experimental intranasal vaccine and its ability to induce an immune response. The study is being conducted at the Cincinnati Children's Hospital Medical Center.
A team of researchers says it has linked sensitivity to an allergen in red meat to the buildup of plaque in the arteries of the heart. While high saturated fat levels in red meat have long been known to contribute to heart disease for people in general, the new finding suggests that a subgroup of the population may be at heightened risk for a different reason -- a food allergen.
In a perspective published today in The Journal of the American Medical Association, National Institutes of Health leadership detail components of a newly released research plan for the Helping to End Addiction Long-term (HEAL) Initiative. The HEAL Initiative is a trans-NIH effort launched in April 2018 to advance national priorities in addressing the opioid crisis through science.
A novel approach to immunotherapy developed by researchers at the National Cancer Institute (NCI) has led to the complete regression of breast cancer in a patient who was unresponsive to all other treatments. This patient received the treatment in a clinical trial led by Steven A. Rosenberg, M.D., Ph.D., chief of the Surgery Branch at NCI's Center for Cancer Research (CCR), and the findings were published June 4, 2018 in Nature Medicine.
An experimental vaccine regimen based on the structure of a vulnerable site on HIV elicited antibodies in mice, guinea pigs and monkeys that neutralize dozens of HIV strains from around the world. The findings were reported today in the journal Nature Medicine by researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and their colleagues.
Some human brains are nearly twice the size of others -- but how might that matter? Researcher have discovered that these differences in size are related to the brain's shape and the way it is organized. The bigger the brain, the more its additional area is accounted for by growth in thinking areas of the cortex, or outer mantle -- at the expense of relatively slower growth in lower emotional, sensory, and motor areas.
Francisella tularensis is the bacterium that causes tularemia, a life-threatening disease spread to humans via contact with an infected animal or through mosquito, tick or deer fly bites. NIAID scientists have unraveled the process by which the bacteria cause disease, finding that F. tularensis tricks host cell mitochondria, which produce energy for the cell, in two different phases of infection. These basic science findings could play a role in developing effective treatment strategies.