A polymorphic region in the human transcription factor AP-2beta gene is associated with specific personality traits
The authors suggest a novel approach in the elucidation of the genetic part of psychiatric disorders and personality; i.e., to identify transcription factor genes as candidate genes in psychiatric disorders and personality. In support of this notion, they show, in the current study, that the personality traits muscular tension, guilt, somatic anxiety, psychasthenia and indirect aggression, as estimated by the Karolinska Scales of Personality (KSP) are significantly related to transcription factor AP-2beta genotype. Since important genes encoding proteins in the dopaminergic and serotonergic system have binding sites for AP-2 in their regulatory regions, one might speculate that the expression of different isoforms of AP-2 influences mood and personality, not only due to their role during the development of the brain, but also due to their function during adulthood.
AUTHORS: M Damberg, H Garpenstrand, J Alfredsson, J Ekblom, K Forslund, G Rylander, L Oreland
Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden; Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden
For further information on this work, please contact Professor Lars Oreland, Department of Neuroscience, Section of Pharmacology, BMC, PO Box 593, S-751 24 Uppsala, Sweden.
Tel: 46-18-471-4092
FAX: 46-18-471-4945
e-mail:lars.oreland@neuro.uu.se
Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs
The neurotransmitter serotonin is thought to play a key role in anxiety and depression and is the target for a very popular class of psychiatric drugs.
This study examined the relationship between a functional polymorphism in the regulatory region of the serotonin transporter gene and anxiety-related personality traits in normal sibling pairs from Israel. Using two different analytical methods -- one which examines the overall relationship between these traits and individuals with differing forms of the gene, and another which studies the differences between siblings who have different forms of the gene -- additional evidence was obtained that this gene affects normal temperament and personality traits. Persons who have the 'short' form of the gene tend to be more anxious, worried, fearful, pessimistic, and cautious than people who have only the 'long' form.
AUTHORS: Y Osher, D Hamer, J Benjamin Beer Sheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, POB 4600, Beer Sheva, Israel; Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA; Soroka Medical Center, Department of Psychiatry, Ben Gurion University of the Negev, POB 151, Beer Sheva, Israel
For further information on this work, please contact Dr. Jonathan Benjamin, Soroka Medical Center, Dept of Psychiatry, POB 151, Beer Sheva 84101, Israel. Tel/FAX: 972-7-6400783
e-mail: yonatan@bgu-mail.bgu.ac.il
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Molecular Psychiatry