News Release

Combinatorial chemistry spurs development of new materials

Powerful tool for discovery and drug development

Peer-Reviewed Publication

Technical Insights



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NEW YORK – May 14, 2002 – Combinatorial chemistry creates vast numbers of compounds by simultaneously reacting a set of components in thousands of different combinations. The technique is continuously altering the way scientists develop new materials and drugs.

“Combinatorial chemistry provides a strong challenge to the traditional way in which industrial chemists work,” says Technical Insights’ Analyst Miriam Nagel. “Executives, engineers, and scientists at pharmaceutical and materials companies are watching closely as industrial chemists decide which is the best way to operate.”

In materials science, discovering new substances is the key to sustaining growth in high-tech products. As with conventional materials discovery programs, combinatorial chemistry is projected to bring a reasonable return on investment when its targets are high-cost, high-value, high-demand materials used in fields such as communications, electronics, photonics, advanced packaging, and self-assembled materials.

Combinatorial chemistry provides a means of increasing the amount of chemical information available to materials discovery groups by a factor of 10,000. Implicit in this huge leap in information is a similarly huge leap in scientific perspective. The ability to observe the properties of thousands of materials nearly simultaneously gives scientists a big-picture view on materials discovery.

Drug companies have been won over by combinatorial chemistry. The pharmaceutical giants have already bought numerous small start-up ventures. The list of products developed using combinatorial methodologies continues to grow.

In the pharmaceutical and biotechnology arena, lead compounds for the treatment of Alzheimer’s disease, tuberculosis, and inflammatory disorders are being developed. Combinatorial drugs for pain, cancer, HIV, lupus, and asthma are in clinical trials.

New analysis by Technical Insights, a business unit of Frost & Sullivan (www.technical-insights.frost.com), Combinatorial Chemistry, reveals that combinatorial chemistry, which originated in the pharmaceutical industry to develop drugs less expensively and more rapidly, will also play an increasingly important role in semiconductor, enzyme, and agricultural-chemical research.

Technical Insights will hold a conference call at 3:00 p.m. (EDT)/ 12 p.m. (PDT) on May 21, 2002 to provide a summary of the latest coverage on combinatorial chemistry. Those interested in participating in the call should send an email to Julia Rowell at jrowell@frost.com with the following information for registration:

Full name, Company Name, Title, Contact Tel Number, Contact Fax Number, Email. Upon receipt of the above information, a confirmation/pass code for the live briefing will be emailed to you.

Frost & Sullivan is a global leader in strategic market consulting and training. Acquired by Frost & Sullivan, Technical Insights is an international technology research business that produces a variety of technical news alerts, newsletters, and reports. The ongoing research on combinatorial chemistry is covered in High Tech Materials Alert, a Technical Insights subscription service and in Lab-on-a-Chip and Proteomics, Technical Insights technology reports. Executive summaries and interviews are available to the press.

Combinatorial Chemistry Report: D235

Contact:
Julia Rowell
P: 210-247-3870
F: 210-348-1003
E: jrowell@frost.com
http://www.frost.com
http://www.technical-insights.frost.com

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