Nine hundred and fifty-seven pregnant HIV-positive women who were between 12 and 27 weeks of gestation were enrolled at 4 clinics in Tanzania. The women averaged 25 years old, with an average weight of 57 kg at their first clinic visit. They were randomly assigned to participate in 1 of 4 regimes: a multivitamin supplement that did not include vitamin A; a vitamin A-alone supplement; a multivitamin supplement that included vitamin A; or, a placebo. During the third trimester, multivitamin use was associated with a small increase in weight gain (averaging 304 g) when compared to the placebo. The risk of weight loss or low weight gain after 26 weeks of gestation was 30% less among women who took multivitamins. Though there was no positive overall association between vitamin A and weight gain, women who received both vitamin A and a multivitamin gained more weight in the second trimester than any of the other groups, and had a 29% lower risk of low weight gain at term.
The authors suggest that multivitamins may possibly improve weight loss patterns in pregnant women by slowing the progression of HIV disease, or by reducing the incidence and severity of secondary infections. The prevention of weight loss is an essential goal of multivitamin supplementation in HIV-infected women because fewer instances of fetal loss, prematurity, intrauterine growth retardation, and infant and maternal mortality will occur.
Villamor, Eduardo. Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women. Am J Clin Nutr 2002;76:1082-90.
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