Bacteria tune-in and turn-on
Miguel Cámara (School of Pharmaceutical Sciences, University of Nottingham, UK) and colleagues review the ways bacteria "tune-in" to each other through a process termed quorum sensing. This cell-to-cell communication allows bacteria to coordinate a unified attack on the host through the production of virulence factors. Communication relies on the production and sensing of small signal molecules. Since the level of signal molecule is a reflection of the population size, bacteria can sense when a quorum of their companions has accumulated sufficient to attack the host. Disruption of quorum sensing might be used to control infection.
athogenesis of infections due to coagulase-negative staphylococci Christof von Eiff and colleagues, Institute of Medical Microbiology, University of Münster Hospital and Clinics, Münster, Germany
Q fever in children Helen C Maltezou and Didier Raoult, Faculté de Médecine, Université de la Méditerranée, Marseille, France
Testosterone therapy in HIV wasting syndrome Anthony Kong and Polly Edmonds, St Bartholomew's Hospital, London, UK