In the present multicenter study, a positive association was identified between OCD and a sequence variant of a serotonergic receptor gene (A-allele of the 5-HT2A-receptor promoter polymorphism -1438G/A). The association suggests that this genetic phenotype is a risk factor for early onset OCD and may represent either a direct or an indirect influence on development of this disorder. The results also indicate that molecular genetic studies should consider age of onset when investigating disease etiology and risk factors.
Citation source: Molecular Psychiatry 2002 Volume 7, number 10, pages 1054-1057.
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