Results published today in the Journal Molecular Cell by Ali Shilatifard, Ph.D., and colleagues show for the first time how a protein known to be involved in the development of cancer functions in normal cells.
The research shows how the protein "Bre1" plays a pivotal role in determining how the protein "Rad6" functions in modification of chromosomal DNA. Also participating in this research was the lab of Dr. Mark Johnston at Washington University School of Medicine.
Dr. Shilatifard, an associate professor of biochemistry and molecular biology at Saint Louis University School of Medicine, said this discovery should lead to several new promising areas of inquiry.
"This opens the door for further study of this protein in the regulation of gene expression," he said. "Once we understand the normal, we will have a better understanding of where something is going wrong."
This, in turn, could lead to ways to block the pathway and ultimately could stop cancer development, Dr. Shilatifard said.
"You can look at a cancer cell as a runaway freight train. There may be a thousand ways to stop it. You can derail it, take all the screws from its wheels or stop giving it fuel. This is one strategy for stopping it."
"Hopefully, together with other researchers, we can come up with a very strong way of stopping the train," he said.
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