Bone marrow or hematopoietic stem cell (HSC) transplantation have recently been used to treat clinically severe autoimmune disease, however they are associated with a high risk of graft rejection or graft-versus-host disease. In contrast, Leonard Harrison and colleagues at the Walter and Eliza Hall Institute of Medical Research, Australia demonstrate that syngeneic transplantation of HSCs does not provoke a host immune response and is capable of preventing autoimmune diabetes in mice.
AUTHOR CONTACT:
Leonard C. Harrison
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Phone: 61-3-9345-2460
Fax: 61-3-9347-0852
E-mail: harrison@wehi.edu.au
View the PDF of this article at: https://www.the-jci.org/press/15995.pdf
Rare reversion of mutation provides a basis for natural gene therapy
A rare inherited disorder known as Wiskott-Aldrich syndrome (WAS) results from a mutation in the WAS protein. Two brothers have been identified that carry a second mutation in this protein, which restored protein function in a fraction of their T cells. Understanding the mechanisms underlying this natural form of gene therapy will be of great importance for developing new therapeutic strategies for genetic disorders.
AUTHOR CONTACT:
Fabio Candotti
NIH, Bethesda, Maryland, USA.
Phone: 301-435-2944
Fax: 301-480-3678
E-mail: fabio@nhgri.nih.gov
View the PDF of this article at: https://www.the-jci.org/press/15485.pdf
Disabling a constitutive CTL epitope allows suppression of autoimmune diabetes by intranasal proinsulin peptide
AUTHOR CONTACT:
Leonard C. Harrison
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Phone: 61-3-9345-2460
Fax: 61-3-9347-0852
E-mail: harrison@wehi.edu.au
View the PDF of this article at: https://www.the-jci.org/press/17166.pdf
ACCOMPANYING COMMENTARY:
Peptide-based treatment for autoimmune diseases: learning how to handle a
double-edged sword
CONTACT:
Alberto Pugliese
Diabetes Research Institution, University of Miami, Miami, Florida, USA
Phone : 305-243-5348
Fax : 305-243-4404
E-mail: apuglies@med.miami.edu
View the PDF of this commentary at: https://www.the-jci.org/press/18395.pdf
Activation of the m opioid receptor provides calm for the colon
Excessive inflammation in the intestine is characteristic of inflammatory bowel disease (IBD). Researchers now show that administration beneath the skin of compounds that selectively inhibit the m opioid receptor in the colon are capable of preventing colitis in mice. These results suggest that such compounds may have therapeutic potential in IBD patients.
CONTACT:
Pierre Desreumaux,
Hopital Huriez, Service de Gastro-enterologie, Lille, France.
Phone: 33-3-2044-4714
Fax: 33-3-2044-4713
E-mail: pdesreumaux@chru-lille.fr
View the PDF of this article at: https://www.the-jci.org/press/16750.pdf
Vasoactive intestinal peptide as a new drug for treatment of primary pulmonary hypertension
AUTHOR CONTACT:
Lutz-Henning Block
University of Vienna, Vienna, Austria.
Phone: 43-1-40400-4774
Fax: 43-1-40400-4784
E-mail: lutz-henning.block@akh-wien.ac.at
View the PDF of this article at: https://www.the-jci.org/press/17500.pdf
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
AUTHOR CONTACT:
Gabriele Bergers
UCSF, San Francisco, California, USA.
Phone : 415-476-6786
Fax : 415-476-0388
E-mail: bergers@cgl.ucsf.edu
View the PDF of this article at: https://www.the-jci.org/press/17929.pdf
ACCOMPANYING COMMENTARY:
Double target for tumor mass destruction
AUTHORS CONTACT:
Kari Alitalo
University Of Helsinki, Helsinki, Finland.
Phone: 358-9-191 25511
Fax: 358-9-191 25510
E-mail: Kari.Alitalo@Helsinki.FI
View the PDF of this commentary at: https://www.the-jci.org/press/18539.pdf
Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
AUTHOR CONTACT:
Shizuo Akira
Osaka University, Osaka, Japan.
Phone: 81-6-6879-8302
Fax: 81-6-6879-8305
E-mail: sakira@biken.osaka-u.ac.jp
View the PDF of this article at: https://www.the-jci.org/press/17085.pdf
ACCOMPANYING COMMENTARY:
Connecting the dots from Toll-like receptors to innate immune cells and
inflammatory bowel disease
AUTHOR CONTACT:
Averil Ma
University Of Chicago, Chicago, Illinois, USA.
Phone: 312-702-4708
Fax: 312-702-2281
E-mail: ama@medicine.bsd.uchicago.edu
View the PDF of this commentary at: https://www.the-jci.org/press/18545.pdf
PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance
AUTHOR CONTACT:
Alan R. Saltiel
The University of Michigan Medical Center, Ann Arbor, Michigan, USA.
Phone : 734-615-9787
Fax : 734-936-2888
E-mail: saltiel@umich.edu
View the PDF of this article at: https://www.the-jci.org/press/17975.pdf
ACCOMPANYING COMMENTARY:
Tissue glycogen content and glucose intolerance
AUTHOR CONTACT:
Masato Kasuga
Kobe University School of Medicine, Kobe, Japan.
Phone: 81-78-382-5860
Fax: 81-78-382-2084
E-mail: kasuga@med.kobe-u.ac.jp
View the PDF of this commentary at: https://www.the-jci.org/press/18526.pdf
Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A
AUTHOR CONTACT:
Michaela Kuhn
University of Muenster, Muenster, Germany.
Phone : 49-251-83-52597
Fax : 49-251-83-55501
E-mail: mkuhn@uni-muenster.de
View the PDF of this article at: https://www.the-jci.org/press/17061.pdf
ACCOMPANYING COMMENTARY:
A friend within the heart: natriuretic peptide receptor signaling
AUTHOR CONTACT:
Jeffrey Molkentin
Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Phone : 513-636-3557
Fax : 513-636-5958
E-mail: MolkJ0@CHMCC.org
View the PDF of this commentary at: https://www.the-jci.org/press/18389.pdf
A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor–deficient mice
AUTHOR CONTACT:
Roland Baron
Yale University School of Medicine, New Haven, Connecticut, USA.
Phone: 203-785-4150
Fax: 203-785-2744
E-mail: roland.baron@yale.edu
View the PDF of this article at: https://www.the-jci.org/press/17246.pdf
Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer
AUTHOR CONTACT:
Roland W. Herzog
The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Phone: 215-590-4907
Fax: 215-590-3660
E-mail: rwherzog@mail.med.upenn.edu
View the PDF of this article at: https://www.the-jci.org/press/16887.pdf
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance
AUTHOR CONTACT:
Ronald Khan
Joslin Diabetes Center, Boston, Massachusetts, USA.
Phone: 617-732-2635
Fax: 617-732-2593
E-mail: Ron.Kahn@joslin.harvard.edu
View the PDF of this article at: https://www.the-jci.org/press/15211.pdf
The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men
AUTHOR CONTACT:
Christos S. Mantzoros
Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Phone: 617-667-2151
Fax: 617-667-2927
E-mail: cmantzor@caregroup.harvard.edu
View the PDF of this article at: https://www.the-jci.org/press/17490.pdf
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