With funding from the NIH (recently extended through 2008), Melloni and doctoral student Jill Grimes have been studying how steroids used during adolescence may permanently alter the brain's ability to produce serotonin. In their experiments, adolescent Syrian hamsters - given their similar brain circuitry to human adolescents - were administered doses of anabolic steroids and then measured for aggressiveness over certain periods of time.
The researchers initially hypothesized that steroid use during adolescence might permanently alter the brain's chemistry and a person's tendency toward aggression long after use has stopped. Their most recent findings, published this week in Hormones and Behavior, enabled them to confirm this hypothesis and conclude that there is indeed a lengthy price - namely long-term aggression - to pay for drug abuse even after the ingestion of steroids ceases.
"We know testosterone or steroids affect the development of serotonin nerve cells, which, in turn, decreases serotonin availability in the brain," Melloni says. "The serotonin neural system is still developing during adolescence and the use of anabolic steroids during this critical period appears to have immediate and longer-term neural and behavioral consequences. What we know at this point is that aggressiveness doesn't simply cease after the ingestion of steroids does."
Based on this research, Melloni also believes that athletes who abuse steroids may also be inclined toward aggressive behavior long after their drug abuse - and musculature - have waned.
Northeastern University, located in the heart of Boston, Massachusetts, is a world leader in cooperative education and recognized for its expert faculty and first-rate academic and research facilities. Through co-op, Northeastern undergraduates alternate semesters of full-time study with semesters of paid work in fields relevant to their professional interests and major, giving them nearly two years of professional experience upon graduation. The majority of Northeastern graduates receive a job offer from a co-op employer. Cited for excellence two years running by U.S. News & World Report, Northeastern was named a top college in the northeast by the Princeton Review 2003/04. In addition, Northeastern's career services was awarded top honors by Kaplan Newsweek's "Unofficial Insiders Guide to the 320 Most Interesting Colleges and Universities," 2003 edition. For more information, please visit http://www.