In an accompanying commentary, Harris Gelbard from the University of Rochester discusses a hypothetical scheme for altered mitochondrial function that may result from the loss of paraplegin activity, which may account for the pathology observed in Spg7-/- mice. A timely therapeutic intervention may therefore prevent axonal loss.
TITLE: Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport
Telethon Institute of Genetics and Medicine, Castellino, Naples, Italy.
View the PDF of this article at: http://www.jci.org/cgi/content/full/113/2/231
ACCOMPANYING COMMENTARY: Synapses and Sisyphus: life without paraplegin
Harris A. Gelbard
University of Rochester Medical Center, Rochester, New York, USA.
Phone: (585) 273-1473
Fax: (585) 506-1947