In the March 15 issue of the Journal of Clinical Investigation, Mark Feinberg and colleagues, of Emory University Vaccine Center, analyze the specific parameters of T-cell activation that may be harmful or helpful in fighting HIV infection by looking at simian immunodeficiency viral (SIV) replication in rhesus macaques where they have blocked CD4 and CD8 T-cell co-stimulation pathways.
The study provides clear evidence for an important role in the immune activation level directly affects the initial peak of virus in the blood stream. They further show that the steady-state viral levels in chronic infection are directly related to the generation of a primary immune response.
Evidence in this study also indicates, indirectly, that immunological response may indeed be harmful by providing increased numbers of target cells for infection. The work here presents the first set of data to differentiate between helpful and harmful effects of the immune response to HIV, and may therefore contribute to new strategies for combating this disease.
An accompanying commentary by Bruce Walker (Harvard Medical School) and Steven Deeks (University of California, San Francisco) provides a detailed discussion of the different components of the findings and how these results aid in picking apart this complex interplay between HIV infection and our immune response.
TITLE: Blockade of T cell costimulation reveals interrelated actions of CD4+ and CD8+ T cells in control of SIV replication
AUTHOR CONTACT:
Mark Feinberg
Emory University Vaccine Center, Atlanta, Georgia, USA
Phone: 404-727-4374
Fax: 404-727-8199
E-mail: mbf@sph.emory.edu
View the PDF of this article at: http://www.jci.org/cgi/content/full/113/6/836
ACCOMPANYING COMMENTARY: The immune response to AIDS virus infection: good, bad, or both?
AUTHOR CONTACT:
Bruce D. Walker
Harvard Medical School, Boston, Massachusetts, USA
Phone: 617-724-8332
Fax: 617-726-4691
E-mail: bwalker@partners.org
Journal
Journal of Clinical Investigation