Study links virus to aggressive breast cancers

A new study finds increasing evidence a virus may play a role in breast cancer. The study, published July 12, 2004 in the online edition of CANCER, a peer-reviewed journal of the American Cancer Society, finds nearly three-quarters of a small sample of Tunisian breast cancer patients showed evidence of a virus similar to one known to cause breast cancer in mice, twice the rate seen in women in the United States. A free abstract of the study will be available via Wiley InterScience (http://www.interscience.wiley.com/cancer-newsroom) upon embargo.

Viruses play a primary role in the development of several cancers, such as the human T-cell lymphotropic virus and adult T-cell leukemia/lymphoma or human herpes virus 8 (HHV8) and Kaposi sarcoma (KS). Geographic variability has also been noted in these cancer-promoting viruses. For example, KS and HHV8 are least common in the U.S. and more common in the Mediterranean and Central African regions.

Existing epidemiological evidence and animal models suggest that a virus may be involved in the development of certain breast cancers. Previous analyses of human breast tissue samples found viral sequences from the mouse mammary tumor virus (MMTV) in a large percentage of breast cancers but not in normal tissue. MMTV may be spread by a species of house mouse that is extremely common in North Africa but less so in the U.S. Studies show that some colonies of these mice are commonly infected with MMTV.

Dr. Paul H. Levine from The George Washington University School of Public Health and Health Services and his colleagues compared 38 samples of breast tumors from patients treated in Tunisia with samples from several other countries.

The authors found that on independent review by two laboratories, a significantly higher proportion of samples from Tunisia tested positive for an MMTV-specific genetic sequence compared to samples from North America, Europe and South America. While 74 percent of Tunisian samples tested positive, other studies reported only 36 percent positive cases from the U.S., 38 percent from Italy, 42 percent from Australia, and 31 percent from Argentina.

Further analysis showed that 89 percent of the MMTV-positive samples were from clinically and histologically aggressive tumors, including trends toward shorter disease-free intervals. The authors conclude: "These findings provide increasing evidence for a human breast cancer virus with geographic differences in prevalence."

Article: "Increasing Evidence for a Human Breast Carcinoma Virus with Geographic Differences," Paul H. Levine, Beatriz G-T Pogo, Afifa Klouj, Stephanie Coronel, Karen Woodson, Stella M. Melana, Nejib Mourali, James F. Holland, CANCER; Published Online: July 12, 2004 (DOI: 10.1002/cncr.20436); Print Issue Date: August 15, 2004.

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