"If we could understand why women have this advantage, we could use that information to one day help both men and women with heart disease," said Crabbe, assistant professor of medicine and a member of the Cardiovascular Research Center at Temple University School of Medicine.
When the heart suffers damage or becomes diseased, it struggles to heal and resume normal functioning. Because the heart is a muscle, healing involves rebuilding. This process, known as cardiac remodeling, is a process of organ repair that may occur differently in men and women, and might explain a woman's survival advantage with heart failure.
To study this phenomenon in depth, Crabbe has received a grant from the National Heart, Lung and Blood Institute to support her project "Sex-Based Differences in Post Infarction Remodeling." This award is supported through Temple's department of physiology in collaboration with her mentor, Steven R. Houser, Ph.D., director of the Cardiovascular Research Center. The project builds on earlier research conducted by Crabbe in which she sought to understand the effect of chronic estrogen loss on cardiac responsiveness to angiotensin II stimulation using isolated hearts.
Crabbe's present study will test whether sex-based differences in cardiac remodeling occur and are mediated through estrogen's effects on activation of the renin-angiotensin system. The renin-angiotensin system is an important neuro-hormonal system involved in the cardiac remodeling process.
Crabbe received a bachelor's degree in engineering from Michigan State University and a doctorate in medicine from Howard University School of Medicine. She underwent postgraduate medical training in cardiology and internal medicine and received advanced subspecialty training in nuclear cardiology and adult cardiac ultrasound imaging. She has completed a research postdoctoral fellowship in physiology at Temple.