Results of this retrospective cohort study, conducted on 198 children who underwent fundoplication at Texas Children's Hospital in Houston from 1996-1999, suggest that fundoplication for the treatment of GERD in children is not the most effective method of short- or long-term treatment for the disease. GERD in young children is often overlooked and is normally outgrown by the time a child reaches their first birthday. However, GERD that develops in older children can be very severe and persistent.
"Fundoplication is not a long-term solution for children with GERD, whether or not they have medical conditions that predispose them to the disease," said Hashem El-Serag, MD, MPH, senior study author. "This study emphasizes the importance of pre-operative counseling on alternative treatment options for GERD in children, as well as an assessment of the risks and benefits involved."
Fundoplication is a procedure which involves surgical strengthening of the sphincter between the esophagus and the stomach. This can reduce the amount of stomach acid that backs up into the esophagus, which can cause repeated vomiting, coughing and other respiratory problems in children.
Currently, there are a number of medical alternatives for GERD, including therapy with histamine-2 receptor antagonists (HRAs), proton pump inhibitors (PPIs) and prokinetics. There are several brands of each of these therapies available by prescription and over-the-counter; however, most of these therapies only provide short-term relief of symptoms. Although endoscopy is another method which provides a simpler way of treating GERD in adults, its long-lasting efficacy has not been determined. Researchers advise patients to discuss alternatives to fundoplication prior to surgery.
About the Study
Lead study author Mark A. Gilger, MD and other researchers at Baylor College of Medicine conducted a retrospective cohort study using the medical records of all children who underwent fundoplication during 1996 and 1999 at Texas Children's Hospital in Houston, TX. There were two groups of children in the study, those who had one or more associated medical conditions (e.g., cystic fibrosis, reactive airway disease) and those who had no pre-existing diseases that increased their risk of developing GERD. Moreover, children with associated medical disorders had an increased incidence of lung infections and dumping syndrome. Findings from this single-center study need to be confirmed in future prospective studies to determine generalizability.
About the AGA
The American Gastroenterological Association (AGA) is dedicated to the mission of advancing the science and practice of gastroenterology. Founded in 1897, the AGA is the oldest medical-specialty society in the United States. The AGA's 14,000 members include physicians and scientists who research, diagnose and treat disorders of the gastrointestinal tract and liver. On a monthly basis, the AGA publishes two highly respected journals, Gastroenterology and Clinical Gastroenterology and Hepatology. The AGA's annual meeting is Digestive Disease Week, which is held each May and is the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.
About Clinical Gastroenterology and Hepatology
The mission of Clinical Gastroenterology and Hepatology is to provide readers with a broad spectrum of themes in clinical gastroenterology and hepatology. This monthly peer-reviewed journal includes original articles as well as scholarly reviews, with the goal that all articles published will be immediately relevant to the practice of gastroenterology and hepatology.