"We believe this is an important first step in understanding not just how estrogen affects learning and memory, but also a variety of non-reproductive behaviors," says Paul Mermelstein, Ph.D., assistant professor of neuroscience at the University of Minnesota and lead researcher. "Estrogen activation of glutamate receptors within other brain regions could also potentially account for the well-documented actions of this hormone on female motor control and pain sensation."
Marissa Boulware, a University of Minnesota neuroscience graduate student who performed the studies states, "Every day post-menopausal women face the dilemma of taking estrogens to improve their cognitive abilities, knowing it may pose a potential heath risk. By better understanding how estrogen acts upon our brain, one day we may develop novel therapies using non-steroidal drugs to mimic the specific actions of estrogen on processes related to learning and memory, affording the cognitive benefits of estrogen without any detrimental side effects."
The research was funded by the National Institutes of Health.