Data from PRECiSE 1 and 2 will be presented in more detail at the major forthcoming gastroenterology medical congresses.
About Crohn'TMs Disease
Crohn'TMs disease is a chronic inflammatory disease of the gastrointestinal tract with the disease typically localized in the terminal part of the ileum (a portion of the small intestine) and right colon (a portion of the large intestine). Crohn'TMs disease affects almost 1 million patients worldwide, with the disease typically appearing early in life. Crohn'TMs disease is characterized by a variety of symptoms, although different in every individual, and may include persistent diarrhea, abdominal pain, and at times loss of appetite/weight, fever or rectal bleeding . Unfortunately there is no single test to diagnose Crohn'TMs disease and because it can often imitate other gastroenterological conditions, patients may experience a lengthy diagnosis process. Although Crohn'TMs disease affects males and females equally of all ages, the most affected in the U.S. are 20-29 year olds and 30-39 year olds . The disease also occurs in young children and adults over 70 years of age. In addition, American Jews of European backgrounds are more likely than the general population to develop Crohn'TMs disease.
Crohn's Disease - United States (Prevalence)
| Yrs of age | 2005 | % |
| 0-9 | 30906 | 8% |
| 10-19 | 32491 | 9 |
| 20-29 | 145598 | 39% |
| 30-39 | 68205 | 18% |
| 40-49 | 23525 | 6% |
| 50-59 | 41850 | 11% |
| 60-69 | 11669 | 3% |
| 70-79 | 11656 | 3% |
| 80+ | 7131 | 2% |
About CIMZIATM
CIMZIATM is a PEGylated Fab'TM fragment of a humanized anti-TNF alpha monoclonal antibody, with high affinity for both soluble and membrane-bound TNF alpha. CIMZIATM is also currently the subject of Phase III clinical trials in rheumatoid arthritis.
About UCB
UCB (www.ucb-group.com) is a global biopharmaceutical leader dedicated to the research, development and commercialization of innovative products in the fields of central nervous system disorders, allergy and respiratory diseases, immune and inflammatory disorders and oncology. UCB employs over 8,500 people operating in over 40 countries. UCB is listed on the Euronext Brussels with a market capitalization of approximately € 5.8 billion. Worldwide headquarters are located in Brussels, Belgium.
UCB Pharma, Inc. is the North American subsidiary of UCB, with U.S. headquarters located in Smyrna, Georgia. UCB'TMs key products in the U.S. are Keppra® (levetiracetam), Zyrtec®' (cetirizine HCl), Tussionex® CIII (hydrocodone polistirex/chlorpheniramine polistirex), and Metadate® CD CII (methylphenidate HCl, USP).
' Zyrtec is licensed to and co-promoted with Pfizer, Inc. in the United States.
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