Public Release: 

A 'smart' bio-nanotube

Novel structure made from cell components could deliver drugs, genes on command

National Science Foundation

By combining one natural component of a cell with the synthetic analog of another component, researchers at the University of California, Santa Barbara, have created a nanoscale hybrid they call the "smart bio-nanotube": a novel structure that could one day become a vehicle for ultra-precise drug or therapeutic gene delivery.

The nanotubes are "smart" because they can open or close at the ends, depending on how the researchers manipulate the electric charge on the two components. So in principle, a nanotube could encapsulate a drug or a gene, and then open on command to deliver the cargo where it would have the best effect.

The tube's components play roles similar to skin and bone. The "skin" is a soap-bubble-like arrangement of molecules known as a lipid bilayer, akin to the bilayer that forms the cell's protective outer membrane. The "bone" is a hollow, cylindrical structure known as a microtubule, which is ubiquitous in the cell's internal cytoskeleton, the system of nanoscale struts and girders it uses for internal transport, structural stability and many other purposes. The researchers have found that when they combine the two components and control the conditions properly, open or closed bio-nanotubes will assemble themselves spontaneously.

The discovery resulted from a collaboration between the laboratories of UCSB materials scientist Cyrus R. Safinya, and UCSB biochemist Leslie Wilson. Their work was funded by the National Science Foundation's biomaterials program and is reported in the Aug. 9 issue of The Proceedings of the National Academy of Sciences. The report also appeared on-line in the PNAS Early Edition.

###

For more information, see the UCSB news release.

NSF-PR 05-133

The National Science Foundation (NSF) is an independent federal agency that supports fundamental research and education across all fields of science and engineering, with an annual budget of nearly $5.47 billion. NSF funds reach all 50 states through grants to nearly 2,000 universities and institutions. Each year, NSF receives about 40,000 competitive requests for funding, and makes about 11,000 new funding awards. The NSF also awards over $200 million in professional and service contracts yearly.

Receive official NSF news electronically through the e-mail delivery and notification system, MyNSF (formerly the Custom News Service). To subscribe, visit http://www.nsf.gov/mynsf/ and fill in the information under "new users".

Useful NSF Web Sites:
NSF Home Page: http://www.nsf.gov
NSF News: http://www.nsf.gov/news/
For the News Media: http://www.nsf.gov/news/newsroom.jsp
Science and Engineering Statistics: http://www.nsf.gov/statistics/
Awards Searches: http://www.nsf.gov/awardsearch/

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.