AAAS, publisher of the journal Science, developed the Signal Transduction Knowledge Environment, an enhanced online journal, known as Science's STKE, that also functions as an electronic resource enabling scientists, researchers, students and educators to find, organize, and use information relevant to cell regulation processes. Leading authorities enter their knowledge about cell signaling into the Connections Maps database, which includes data on signaling components and their relationships organized into pathways.
Genomatix developed the BibliospherePE pathway knowledge base and analysis system. It allows for dynamic data-driven network/pathway construction and analysis based on literature, the Genomatix Knowledge Base, and sequence analysis. It is an important component of the microarray data analysis pipeline offered by Genomatix and enables biologists to discover, explore and understand biologically relevant pathways down to the molecular level. Applying the Genomatix pipeline to a researcher's set of genes (for example, from a microarray analysis) generates the full biological network, allowing for functional analysis of the most relevant sub-network and enables understanding of gene regulatory mechanisms on DNA sequence level.
"The STKE database is a great synergistic expansion to our BiblioSPherePE knowledge base. Following our strategy to only include highest quality data backed by well known scientific authorities, I couldn't think of any better source than STKE published by AAAS along with the leading scientific weekly, Science," says Klaus May, head of sales and marketing at Genomatix.
"The combination of signal transduction pathways, metabolic pathways, transcription factor knowledge, promoter sequence analysis, different Gene Ontology and MESH filters -- all in one dynamically overlayable package -- makes BiblioSpherePE even more powerful and essential for molecular biology research."
About AAAS
The American Association for the Advancement of Science (AAAS) is the world's largest general scientific society, and publisher of the journal Science (www.sciencemag.org), Science's STKE (www.stke.org), and Science's SAGE KE (http://sageke.sciencemag.org). AAAS was founded in 1848, and serves some 262 affiliated societies and academies of science, serving 10 million individuals. Science has the largest paid circulation of any peer-reviewed general science journal in the world, with an estimated total readership of 1 million. The nonprofit AAAS (www.aaas.org) is open to all and fulfills its mission to "advance science and serve society" through initiatives in science policy; international programs; science education; and more. For the latest research news, log onto EurekAlert!, www.eurekalert.org, the premier science-news Web site, a service of AAAS.
About Genomatix Software GmbH
Genomatix was founded 1997 as a spin-off from the GSF - National German Research Center for Environment and Health. It developed a multilayer integrative approach aimed at understanding differential gene expression and regulation at the molecular level. Genomatix offers a complete solution from microarray analysis, via pathway knowledge bases and analysis, down to regulatory sequence analysis for transcriptional co-regulation. Genomatix enables better understanding of biological mechanisms under different conditions and stimuli and helps to discover new contexts from biological data. Genomatix has more than 160 peer reviewed scientific publications which are cited in more than 3,700 papers. Genomatix tools and databases are applied by more than 24,000 researchers worldwide.