In a study of over 800 patients, Badellino and colleagues now found a link between high EL concentrations in the blood, low levels of HDL-C, and early stages of atherosclerosis. This suggests that EL concentrations influence the development of atherosclerosis in humans as well and might be useful to predict an individual's risk.
Citation: Badellino KO, Wolfe ML, Reilly MP, Rader DJ (2006) Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis. PLoS Med 3(2): e22.
Dr. Karen Badellino
University of Pennsylvania
Institute for Experimental Medicine and Therapeutics
Room 646 BRB II/III
421 Curie Blvd
Philadelphia, PA USA 19104
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