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Journal of Alzheimer's Disease is devoted to metal ions and neurodegenerative diseases

Volume 8, Issue 2

Case Western Reserve University

The human body contains many metals, from the iron in hemoglobin to the calcium in bones. Other metals, usually in trace amounts, participate in many metabolic and degenerative processes. The recent issue of the Journal of Alzheimer's Disease (Volume 8, Issue 2) published by IOS Press is devoted to "Metal Ions and Neurodegenerative Diseases" and presents a collection of important papers dedicated to uncovering the role of various metals in human neurophysiology and neurodegenerative disorders, particularly Alzheimer's Disease.

Guest editor Paolo Zatta, CNR-Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padova, Italy, sets the stage for the special issue. "Metal ions are essential building blocks for life. However, they are also deeply implicated in pathological events related to their depletion or abnormal accumulation in human and animal tissues, mainly the brain, with consequent neurodegenerative phenomena," he writes in the foreword, dedicated to Professor Marino Nicolini. "In the last three decades abundant scientific literature has attributed an important role to metal ions in neurodegenerative disorders such as Alzheimer's (AD), Parkinson's, Huntingtons's, Menkes' and Wilson's diseases, as well as amyotrophic lateral sclerosis, prion diseases and others."

The issue contains 11 research and review papers, a conference report from the 3rd International Conference on Metals and the Brain and the transcript of a live discussion among leading researchers in the field.

With papers covering iron and aluminum metabolism, zinc biochemistry, calcium and copper disorders, and other metal-related pathologies, this special issue provides key insights into the neurological effects of metals in the human body.


Table of Contents is below for Journal of Alzheimer's Disease, Volume 8, Issue 2

Full text of articles is available upon request. Please contact

Zinc dyshomeostasis: A key modulator of neuronal injury
Margherita Capasso, Jade-Ming Jeng, Marco Malavolta, Eugenio Mocchegiani, Stefano L. Sensi

Metallothionein-I-II and GFAP positivity in the brains from frontotemporal dementia patients
P. Zatta, P. Zambenedetti, M. Musicco, F. Adorni

Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells
Peter N. Alexandrov, Yuhai Zhao, Aileen I. Pogue, Matthew A. Tarr, Theo P.A. Kruck, Maire E. Percy, Jian-Guo Cui, Walter J. Lukiw

Amyloid-â: Acute-phase apolipoprotein with metal-binding activity
Anatol Kontush

The role of MT in neurological disorders
Michael Aschner and Adrian K. West

Calcium in Alzheimer's disease pathogenesis: Too much, too little or in the wrong place?
Lorella M.T. Canzoniero and B. Joy Snider

Is zinc the link between compromises of brain perfusion (excitotoxicity) and Alzheimer's disease?
Christopher J. Frederickson, Math P. Cuajungco, Cathleen J. Frederickson

Imbalance between pro-oxidant and pro-antioxidant functions of zinc in disease
Qiang Hao and Wolfgang Maret

Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases
Masahiro Kawahara

Iron, neuroinflammation, and Alzheimer's disease
Wei-Yi Ong and Akhlaq A. Farooqui

Involvement of amyloid â precursor protein (AâPP) modulated copper homeostasis in Alzheimer's disease
Thomas A. Bayer and Gerd Multhaup

It's all in the metals: Report on the 3rd International Metals and Brain symposium at a combined meeting of the International Brain Research Organisation (IBRO), the Society of Neuroscientists of Africa (SONA), and the Collegium Internationale Neuro-psychopharmacologicum (CINP) in Cape Town, South Africa, 22 April 2005
Stefano L. Sensi and Susan van Rensburg

Alzheimer Research Forum Live Discussion: Role and control of metal-mediated fibril toxicity

About the Journal of Alzheimer's Disease
The Journal of Alzheimer's Disease ( is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer's disease.

About IOS Press
Commencing its publishing activities in 1987, IOS Press ( is a rapidly expanding scientific, technical, medical and professional publishing house focusing on a broad range of subject areas. Headquartered in Amsterdam, IOS Press publishes approximately 100 new books per annum and 70 international journals, covering topics ranging from computer science and mathematics to medicine and the natural sciences. Electronic access to all journals is now available. IOS Press also maintains offices in the Washington, DC area and Berlin and a co-publishing relationship with Ohmsha, Ltd (Tokyo).

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