Red wine components modulate tissue damage induced by bacteria in gum diseases

Researchers are finding that components found in red wine can help in preventing and treating inflammatory periodontal diseases. Periodontitis is a progressive infectious disease affecting the gums and bone that surround and support teeth, often causing tooth movement and leading to permanent tooth loss. About 15% of adults between 21 and 50 years of age and 65% of adults over 50 are affected by this disease.

In recent years, the benefits of consuming fresh fruits and yellow-green vegetables and beverages, particularly green tea and red wine, have been reported to reduce human cancer incidence and mortality. The potential health benefits of those products are attributed to a broad range of compounds called polyphenols. Recent studies have also shown that red wine, and particularly grape seeds, possesses anti-inflammatory and anti-tumor activities and prevent heart disease. Mechanisms by which these phenolic compounds exert their protective effects include their anti-oxidant properties.

Scientists from Université Laval (Québec, Canada), reporting today at the 35th Annual Meeting of the American Association for Dental Research, conducted a study to investigate the role of polyphenols, including those from red wine, in scavenging free radicals released by immune cells stimulated with components of bacteria causing periodontal diseases. Because free radicals are generated by immune cells during periodontitis, it is critical to keep them at low levels to maintain healthy gums. Their results indicated that red wine polyphenols significantly modulate several inflammatory components released by macrophages (a population of host immune cells) in response to bacterial stimuli. Specifically, polyphenols efficiently scavenged and inhibited free-radical generation by host immune cells by controlling intracellular proteins involved in their release. These anti-oxidant properties of red wine polyphenols could be useful in the prevention and treatment of inflammatory periodontal diseases as well as other disorders involving free radicals.

This is a summary of abstract #1080, "Red Wine Polyphenols Modulate the Oxidative Stress Induced by Periodontopathogens", by V. Houde, D. Grenier, and F. Chandad, of Université Laval, Québec, Canada, to be presented at 2 p.m. on Friday, March 10, 2006, in Pacific Hall of the Walt Disney World Dolphin Hotel, during the 35th Annual Meeting of the American Association for Dental Research.

Interested readers may want to refer to an article in the March, 2006, issue of the Journal of Dental Research, "Anti-inflammatory Activity of a High-molecular-weight Cranberry Fraction on Macrophages Stimulated by Lipopolysaccharides from Periodontopathogens", by C. Bodet et al. of Laval University, Montreal, PQ, Canada (J Dent Res 85[3]:235-239, 2006).

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