Cold Spring Harbor, N.Y., Tues., Aug. 1, 2006 - The current issue of Cold Spring Harbor Protocols, published online today, features new, freely available methods for using RNA interference (RNAi) in mice and Drosophila. RNAi is a technique that allows researchers to specifically block the action of individual genes without affecting the expression of others. These protocols--contributed by leading scientists in the RNAi field--will be useful to many researchers seeking to identify the biological functions of genes in important biological model systems.
Among the more than 50 new methods published today are protocols for handling embryonic stem cells, visualizing events leading to programmed cell death, and preparing cells and proteins for microscopic imaging. The latest issue adds greater depth to the substantial archive of protocols that has been available since the launch of this new scientific resource in May of 2006.
CSH Protocols(www.cshprotocols.org) is an online journal of techniques used in a wide range of biology laboratories. Each protocol is clearly presented and designed for easy use at the bench--complete with reagents, equipment, and recipe lists. CSH Protocols is structured as an interactive database, with each protocol cross-linked to related methods, descriptive information panels, and illustrative material to maximize the total information available to investigators.
All methods are peer-reviewed, citable publications that are meticulously edited to ensure technical accuracy. Life science researchers can access the entire collection via institutional site licenses, and can add their suggestions and comments to further refine the techniques.
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