COLD SPRING HARBOR, N.Y. (Tues., May 1, 2007) - Physical alterations of DNA in chromosomes can cause serious diseases such as Down syndrome, Prader-Willi syndrome, or cancer. Likewise, changes to the physiological environment of cells--with drugs or toxins, for example--can alter their metabolic output. To track these processes, scientists need ways to mark genes and their protein products. This month's release of Cold Spring Harbor Protocols (www.cshprotocols.org) features freely available methods for marking molecules to identify gene alterations and metabolic shifts.
The first method (http://www.
To identify structural features and abnormalities in chromosomes, scientists need to tag DNA probes with visual markers. The second freely available method (http://www.
ABOUT COLD SPRING HARBOR PROTOCOLS:
Cold Spring Harbor Protocols (www.cshprotocols.org) is an online resource of methods used in a wide range of biology laboratories. It is structured to be highly interactive, with each protocol cross-linked to related methods, descriptive information panels, and illustrative material to maximize the total information available to investigators. Each protocol is clearly presented and designed for easy use at the bench--complete with reagents, equipment, and recipe lists. Life science researchers can access the entire collection via institutional site licenses, and can add their suggestions and comments to further refine the techniques.
ABOUT COLD SPRING HARBOR LABORATORY PRESS:
Cold Spring Harbor Laboratory Press is an internationally renowned publisher of books, journals, and electronic media located on Long Island, New York. It is a division of Cold Spring Harbor Laboratory, an innovator in life science research and the education of scientists, students, and the public. For more information, visit www.cshlpress.com.