Public Release: 

Heeding the WARNing from malaria's past

BioMed Central

A global network to monitor drug resistance and guide malaria treatment and prevention policies is being launched.

As outlined in a series of articles in the online open access publication, Malaria Journal, the World Antimalarial Resistance Network (WARN) aims to provide a globally co-ordinated effort to tackle the disease, which is estimated to kill between 1 and 2.7 million people every year.

One of the major aims of WARN is to facilitate worldwide monitoring and characterisation of drug resistance, particularly that to the latest generation of antimalarial drugs, artemisinin-based combination therapies (ACTs).

WARN will consist of four linked, global, open-access, web-based databases containing four kinds of data:

  • Clinical drug efficacy
  • In vitro response of malaria parasites to drugs
  • Prevalence of molecular markers of drug resistance
  • Pharmacological properties of drugs in different groups of patients

The databases will include freely available tools to make adding information straightforward, and to give researchers the opportunity to analyse and use information from the databases in a variety of ways. Information on individual patients will be collated in a standardised way, which should make it easier for researchers to compare directly or pool data from different sites across the world.

WARN's founders hope that the databases will help speed up the publication process for scientists. This, in turn, means that policymakers and malaria control managers will have access to timely information on the temporal and geographic trends of drug resistance, allowing them to take action as soon as resistant malaria parasites are detected.

Drug resistance is a major threat to the control and eradication of malaria and can lead to treatment failure, increased spread of the disease, and higher morbidity and mortality. Many 'old' antimalarials, including chloroquine and mefloquine, are now of limited use because of drug resistance.

Today, over 50 countries recommend ACTs as first-line therapy for falciparum malaria, the most severe form of the disease. While these newer treatments are currently effective, researchers know that resistance to ACTs will emerge in the future.

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The network is being launched after a meeting of leading malaria researchers and policymakers sponsored by the Bill and Melinda Gates Foundation held at the Wellcome Trust/Sanger Centre, Cambridge, UK in late 2006

Articles:

The rationale and plan for creating a World Antimalarial Resistance Drug Network (WARN)
Carol H. Sibley, Karen I Barnes and Christopher V Plowe
Malaria Journal (in press)

World Antimalarial Resistance Network (WARN) I: Clinical efficacy of antimalarial therapy
Ric N. Price, Grant Dorsey, Elizabeth A. Ashley, Karen I. Barnes, J. Kevin Baird, Umberto d'Alessandro, Philippe J. Guerin, Miriam K. Laufer, Inbarani Naidoo, Francois Nosten, Piero Olliaro, Christopher V. Plowe, Pascal Ringwald, Carol H. Sibley, Kasia Stepniewska and Nicholas J. White
Malaria Journal (in press)

World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility
David J Bacon, Ronan Jambou, Thierry Fandeur, Jacques Le Bras, Chansuda Wongsrichchanalai, Mark M Fukuda, Pascal Ringwald, Carol H. Sibley and Dennis E Kyle
Malaria Journal (in press)

World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria
Christopher V. Plowe, Cally Roper, John W. Barnwell, Christian T. Happi, Hema H. Joshi, Wilfred Mbacham, Steven R. Meshnick, Kefas Mugittu, Inbarani Naidoo, Ric N. Price, Robert W. Shafer, Carol H. Sibley, Colin J. Sutherland, Peter A. Zimmerman and Philip J. Rosenthal
Malaria Journal (in press)

World Antimalarial Resistance Network (WARN) IV: Clinical pharmacology
Karen I. Barnes, Niklas Lindegardh, Olumide Ogundahunsi, Piero Olliaro, Christopher V. Plowe, Milijaona Randrianarivelojosia, Grace O. Gbotosho, William M. Watkins, Carol H. Sibley and Nicholas J. White
Malaria Journal (in press)

During embargo, article available at:
http://www.malariajournal.com/imedia/2008665112138004_article.pdf"random=32247
http://www.malariajournal.com/imedia/1858516738138006_article.pdf"random=456817
http://www.malariajournal.com/imedia/3434255371380065_article.pdf"random=916965
http://www.malariajournal.com/imedia/7266297761380082_article.pdf"random=959458
http://www.malariajournal.com/imedia/5134147913800686_article.pdf"random=98172

After the embargo, article available from the journal website at:
http://www.malariajournal.com/

Article citation and URL available on request at press@biomedcentral.com on the day of publication

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