Scientists at the Institute of Food Research have highlighted possible consequences of fortifying flour with folic acid due to new evidence of how it is absorbed by the body.
In May, the Food Standards Agency's Board agreed unanimously that 'mandatory fortification' with folic acid should be introduced to make sure the number of babies born with neural tube defects is reduced. This means that it would be compulsory to add folic acid to either bread or flour.
Folic acid is a synthetic form of folate, a B vitamin found in a wide variety of foods including liver and green leafy vegetables. Folates are metabolised in the gut, whereas in a paper to be published in the British Journal of Nutrition in October IFR scientists suggest that folic acid is metabolised in the liver. The liver is an easily saturated system, and fortification could lead to significant unmetabolised folic acid entering the blood stream, with the potential to cause a number of health problems.
"Fortifying UK flour with folic acid would reduce the incidence of neural tube defects", said Dr Siân Astley of the Institute of Food Research. "However, with doses of half the amount being proposed for fortification in the UK, the liver becomes saturated and unmetabolised folic acid floats around the blood stream.
"This can cause problems for people being treated for leukaemia and arthritis, women being treated for ectopic pregnancies, men with a family history of bowel cancer, people with blocked arteries being treated with a stent and elderly people with poor vitamin B status. For women undergoing in-vitro fertilisation, it can also increase the likelihood of conceiving multiple embryos, with all the associated risks for the mother and babies.
"It could take 20 years for any potential harmful effects of unmetabolised folic acid to become apparent".
It has already been shown that folic acid forticifation can exhibit Jekyll and Hyde characteristics, providing protection in some people while causing harm to others. For example, studies have confirmed that unmetabolised folic acid accelerates cognitive decline in the elderly with low vitamin B12 status, while those with normal vitamin B12 status may be protected against cognitive impairment. Most over 65s in the UK have low B12 status.
Similarly, dietary folates have a protective effect against cancer, but folic acid supplementation may increase the incidence of bowel cancer. It may also increase the incidence of breast cancer in postmenopausal women.
Since the 1980s a consensus formed that that folic acid is metabolised in the small intestine in a similar way to naturally-occuring folates. This consensus was used to assess the safety of folic acid fortification.
"We challenge the underlying scientific premise behind this consensus", said Dr Astley. "This has important implications for the use of folic acid in fortification, because even at low doses it could lead to over consumption of folic acid with its inherent risks".
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Notes to editors
- Full reference for the paper: British Journal of Nutrition (2007), October, 98.4 "Folic acid metabolism in human subjects revisited: potential implications for proposed mandatory folic acid fortification in the UK"
- The mission of the Institute of Food Research (www.ifr.ac.uk) is to undertake international quality scientific research relevant to food and human health and to work in partnership with others to provide underpinning science for consumers, policy makers, the food industry and academia. It is a company limited by guarantee, with charitable status, grant aided by the Biotechnology and Biological Sciences Research Council (www.bbsrc.ac.uk).
- About BBSRC The Biotechnology and Biological Sciences Research Council (BBSRC) is the UK funding agency for research in the life sciences. Sponsored by Government, BBSRC annually invests around £380 million in a wide range of research that makes a significant contribution to the quality of life for UK citizens and supports a number of important industrial stakeholders including the agriculture, food, chemical, healthcare and pharmaceutical sectors. BBSRC carries out its mission by funding internationally competitive research, providing training in the biosciences, fostering opportunities for knowledge transfer and innovation and promoting interaction with the public and other stakeholders on issues of scientific interest. For more information on BBSRC go to: www.bbsrc.ac.uk
- For more on the decision of the FSA Board: http://www.
food. gov. uk/ news/ newsarchive/ 2007/ jun/ folateupdate