image: Molecular Biology of the Cell, Fifth Edition view more
Credit: Garland Science
Since the first edition published 25 years ago, Molecular Biology of the Cell has become the leading cell biology textbook, lauded as “the most influential cell biology textbook of its time” [1] . It has been read by well over one million people around the world.
The new fifth edition continues to build on its tradition of scientific authority, accuracy, and clarity. The book has been completely revised and updated to reflect our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics, stem cells, RNAi, comparative genomics, cancer therapies, apoptosis, cell cycle control and the mechanics of M phase.
The hallmark features of Molecular Biology of the Cell that have endeared themselves to generations of readers have been retained. Additionally, the authors have incorporated new features into the fifth edition in response to feedback from readers. For the first time, end-of-chapter questions have been included. Every copy of the fifth edition comes with the Media DVD-ROM which includes all of the figures in the book preloaded into PowerPoint® presentations, and the Cell Biology Interactive Media Player containing over 150 movies—animations, videos, and molecular models—all with voice-over narration.
By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and thereby create a coherent framework through which readers may approach and enjoy this subject that is so central to all of biology.
Contents in Brief
I. Introduction to the Cell
1. Cells and Genomes
2. Cell Chemistry and Biosynthesis
3. Proteins
II. Basic Genetic Mechanisms
4. DNA, Chromosomes and Genomes
5. DNA Replication, Repair, and Recombination
6. How Cells Read the Genome: From DNA to Protein
7. Control of Gene Expression
III. Methods
8. Manipulating Proteins, DNA, and RNA
9. Visualizing Cells
IV. Internal Organization of the Cell
10. Membrane Structure
11. Membrane Transport of Small Molecules and the Electrical Properties of Membranes
12. Intracellular Compartments and Protein Sorting
13. Intracellular Vesicular Traffic
14. Energy Conversion: Mitochondria and Chloroplasts
15. Mechanisms of Cell Communication
16. The Cytoskeleton
17. The Cell Cycle
18. Apoptosis
V. Cells in Their Social Context
19. Cell Junctions, Cell Adhesion, and the Extracellular Matrix
20. Cancer
21. Sexual Reproduction: Meiosis, Germ Cells, and Fertilization
22. Development of Multicellular Organisms
23. Specialized Tissues, Stem Cells, and Tissue Renewal
24. Pathogens, Infection, and Innate Immunity
25. The Adaptive Immune System
Glossary
Index
[1] Friedberg, Errol C. (2004). The Writing Life of James D. Watson. Cold Spring Harbor Laboratory Press. ISBN 0879697008.
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