Aberrant mucin assembly induces colitis
Michael McGuckin (of the Mater Medical Research Institute, South Brisbane, Australia) and colleagues identify two mutations that cause aberrant mucin oligomerization in mice. The resulting phenotype, including endoplasmic reticulum stress, resembles clinical and pathologic features of human ulcerative colitis.
Citation: Heazlewood CK, Cook MC, Eri R, Price GR, Tauro SB, et al. (2008) Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med 5(3): e54.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050054
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-03-mcguckin.pdf
CONTACT:
Michael McGuckin
Mater Medical Research Institute
Mucosal Diseases Program
South Brisbane, QLD 4101
Australia
+61-7-31632568
+61-7-31632555 (fax)
mmcguckin@mmri.mater.org.au
FROM THE PLoS MEDICINE MAGAZINE SECTION
An open-source solution to the problem of managing trial data
Research organizations and funders should combine efforts to produce an open-source solution for trial data management, say two researchers in an Essay in this week’s PLoS Medicine.
Many research institutions worldwide lack the skills or resources to establish and use software systems required to manage clinical trial data in compliance with international standards for trial conduct.
Greg Fegan and Trudie Lang from the Kenya Medical Research Institute–Wellcome Trust Collaborative Research Programme in Kilifi, Kenya argue that “an open-source approach to a truly designed-for-purpose data management system for clinical trials is attractive.” Such a system would save money, they argue, by eliminating the reliance on the use of expensive database software systems and their administrators.
“This would empower and enable a wider variety of people to conduct trials, as the question of capturing, cleaning, and extracting data would not be overly daunting or expensive,” they say. In turn, an open-source trial data management system “may encourage more investigators in resource-poor settings to take part in high-standard research that would otherwise be out of reach and beyond their capacity.”
Citation: Fegan GW, Lang TA (2008) Could an open source clinical trial data-management system be what we have all been looking for? PLoS Med 5(3): e6.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050006
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-03-lang.pdf
CONTACT:
Trudie Lang
Kemri-Wellcome Programme
Clinical Trials
PO Box 230
Kilfi, Coast 230
Kenya
+254 720130908
tlang@kilifi.kemri-wellcome.org
About PLoS Medicine
PLoS Medicine is an open access, freely available international medical journal. It publishes original research that enhances our understanding of human health and disease, together with commentary and analysis of important global health issues. For more information, visit http://www.plosmedicine.org
About the Public Library of Science
The Public Library of Science (PLoS) is a non-profit organization of scientists and physicians committed to making the world's scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org
Journal
PLoS Medicine