image: Thamnophis sirtalis eating a tetrodotoxic Taricha granluosa. view more
Credit: Edmund D. Brodie III
Animals are poisonous to prevent other animals from eating them. However, a new study published this week in the open-access journal PLoS Biology investigating the toxic rough-skinned newt finds that, despite being among the most poisonous known animals, in some regions these newts have no effect on their main predator, the garter snake, as these slippery serpents have evolved resistance to a poison so strong that one-newtsworth can kill thousands of mice.
The garter snake and the rough-skinned newt are a typical example of a co-evolutionary arms race: two groups, in this case predators versus prey, competing to survive and reproduce optimally. The two groups evolve interacting traits as each struggles to outcompete the other; the prey animal may evolve poison and, in response, the predator evolves resistance and then the prey evolves a stronger poison, etc. However, a paper published this week by Charles Hanifin and colleagues finds that in the newt-snake system, some snakes have managed to "escape" from this battle by becoming super-resistant.
Hanifin and colleagues studied the interaction between the two species all the way from British Columbia to Southern California. As expected, if the two traits have evolved in a tit-for-tat way, areas where the newts were most toxic were also those where the snakes were most resistant. However, surprisingly, they found that often the snakes had "won" by becoming resistant to even the most toxic local newt. Where traits are mismatched in this "snake-always-wins" way a third of the studied location there is no scope for further evolution of the conflict.
What has allowed the snakes this crushing victory" Hanifin found that some of the most resistant snakes differed only in 1 unit of their genetic code and that this tiny change had altered the structure of a snake protein enough that the toxin could no longer bind to it. This is a fantastic example of how a single random mutation can generate a major change in an animal.
Citation: Hanifin CT, Brodie ED Jr, Brodie ED III (2008) Phenotypic mismatches reveal escape from arms-race coevolution. PLoS Biol 6(3): e60. doi:10.1371/journal.pbio. 0060060
CONTACT:
Charles Hanifin
Stanford University
Hopkins Marine Station
+1-831-655-6220
+1-831-375-0793 (fax)
charlesh@stanford.edu
PLEASE MENTION THE OPEN-ACCESS JOURNAL PLoS BIOLOGY (www.plosbiology.org) AS THE SOURCE FOR THESE ARTICLES AND PROVIDE A LINK TO THE FREELY-AVAILABLE TEXT. PLEASE NOTE: THE CORRECT CITATION IS PLoS BIOLOGY, NOT PUBLIC LIBRARY OF SCIENCE BIOLOGY. THANK YOU.
All works published in PLoS Biology are open access. Everything is immediately available to read, download, redistribute, include in databases, and otherwise use, without cost to anyone, anywhere, subject only to the condition that the original authorship and source are properly attributed. Copyright is retained by the authors. The Public Library of Science uses the Creative Commons Attribution License.
Journal
PLoS Biology