CHICAGO - People with Alzheimer's disease who take vitamin E appear to live longer than those who don't take vitamin E, according to research that will be presented at the American Academy of Neurology 60th Anniversary Annual Meeting in Chicago, April 12-19, 2008.
For the study, researchers followed 847 people with Alzheimer's disease for an average of five years. About two-thirds of the group took 1,000 international units of vitamin E twice a day along with an Alzheimer's drug (a cholinesterase inhibitor). Less than 10 percent of the group took vitamin E alone and approximately 15 percent did not take vitamin E.
The study found people who took vitamin E, with or without a cholinesterase inhibitor, were 26 percent less likely to die than people who didn't take vitamin E.
"Vitamin E has previously been shown to delay the progression of moderately severe Alzheimer's disease. Now, we've been able to show that vitamin E appears to increase the survival time of Alzheimer's patients as well," said study author Valory Pavlik, PhD, with Baylor College of Medicine's Alzheimer's Disease and Memory Disorders Center in Houston, TX, and member of the American Academy of Neurology. "This is particularly important because recent studies in heart disease patients have questioned whether vitamin E is beneficial for survival."
In addition, the study found vitamin E plus a cholinesterase inhibitor may be more beneficial than taking either agent alone. "Our findings show that people who took a cholinesterase inhibitor without vitamin E did not have a survival benefit," said Pavlik. "More research needs to be done to determine why this may be the case."
In addition to vitamin E supplements, some vegetables oils, nuts, and green leafy vegetables are main food sources of vitamin E. Some fortified cereals in the United States also contain vitamin E. "The daily amount of vitamin E taken by patients in this study was much higher than what is currently recommended for the general population," said Pavlik.
The American Academy of Neurology, an association of over 21,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer's disease, epilepsy, multiple sclerosis, Parkinson's disease, and stroke.
For more information about the American Academy of Neurology, visit www.aan.com.
Editor's Note: Dr. Pavlik will present this research during a scientific poster session at 4:00 p.m. CT/5:00 p.m. ET, on Tuesday, April 15, 2008, in the Exhibit Hall of McCormick Place West Convention Center.
She will be available for media questions during a press briefing at 11:00 a.m. CT/12:00 p.m. ET, on Tuesday, April 15, 2008, in the on-site Press Interview Room, room 182. If you are a member of the media interested in listening to the press briefing via conference call, please call the AAN Press Room (April 12 - 18) at (312) 791-7053.