Public Release: 

Unlocking the promise of clinical and translational science

Diseases targeted at molecular level before patient feels sick


Philadelphia, PA - May 21, 2008 - If you were sick, wouldn't you prefer a customized medical treatment that works specifically for you" Or a treatment that prevents you from ever getting sick in the first place" The emerging field of clinical and translational science provides the bridging force that transforms lab discoveries into customized, patient-specific therapy. Deputy Editor, Scott A. Waldman, MD, PhD, and Executive Editor, Andre Terzic, MD, PhD, discuss clinical and translational science and its impact on our healthcare in the first issue of the journal CTS: Clinical and Translational Science.

"Diseases ultimately originate from abnormalities in the individual molecules controlling the function of normal cells. Defining those molecules and their normal and abnormal interactions for each disease state creates opportunities to repair malfunctions and restore cells to normal health," explains Waldman. Thus, defining mechanisms at the molecular level underlying disease is the key to designing better methods for diagnosing, treating and preventing disease.

Success will require decoding abnormal genetic programming, eventually at birth, and identifying any acquired genetic abnormalities over your lifetime. The role the environment plays in our disease development will also have to be defined.

Clinical and translational medicine holds the promise of helping physicians establish individualized disease risk, preventing disease development and ultimately creating personalized therapeutic intervention for their patients. This new approach will in turn allow healthcare to transform from a reactive model to a more powerful, preemptive one.

Researchers and clinicians are realizing in order to turn the hype of genome-related medical breakthroughs into reality, their work will have to evolve into a multidimensional approach to medicine. This will incorporate basic research, clinical practice and interdisciplinary education, along with collaboration among diverse scientific and clinical fields.

"In the long-run, the success of this discipline will result in innovative diagnostic and therapeutic tools to predict, prevent and cure disease in patients, individually and across global populations," conclude Waldman and Terzic.


This study is published in the May 2008 issue of CTS: Clinical and Translational Science. Media wishing to receive a PDF of this article may contact

Scott A. Waldman, MD, PhD, FCP, is Deputy Editor of the journal and is affiliated with Thomas Jefferson University. Dr. Waldman can be reached for questions at

CTS: Clinical and Translational Science is your source for the most current and thought provoking original research across the broad spectrum of clinical specialties and basic science. CTS highlights investigative work bridging the gap between laboratory discovery and practice. CTS will discuss the state-of-the-science and strategies that will accelerate the assimilation of genomics and proteomics information into the clinic. This peer-reviewed journal provides a clear picture of the rich and complex world that is such a part of translational medicine. For information, please visit

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