Gardner syndrome (GS) is a rare, autosomal, dominant inherited disorder with a high degree of penetrance characterized by the triad: intestinal polyposis and various bone and soft-tissue tumors. It is regarded as a clinical subgroup of familial adenomatous polyposis (FAP).
This case, reported by a team led by Dr. Shi-Lin Wang, is described in a research article to be published on April 7, 2008 in the World Journal of Gastroenterology.
A 23-year-old female presented with nausea, vomiting and mucous diarrhea with occasional blood in the stool, especially after dining. Colonoscopy delineated numerous polyps carpeting the entire colon and rectum, mostly in the sigmoid colon and rectum, which is consistent with the diagnosis of FAP. Gastroscopy delineated numerous polyps carpeting mainly the fundus ventriculi but also the corpus ventriculi. The patient was treated with restorative proctocolectomy with ileal pouch anal anastomosis (RPC/IPAA), ileostomy and ileostomy closure operations, and twice with snare polypectomy over an eight month period. The patient gradually recovered from innutrition and anemia.
It was reported that 25% of patients with GS had no family history; moreover the miniaturization of family also made the hereditary behavior unobvious. When faced with a patient with colorectal polypi in the clinic, doctors should pay attention to examining the patient¡¯s stomach, thyroid, tooth, skull and eye ground. The examination of APC and MYH mutation are helpful in diagnosing patients with GS and FAP.
Reference: Gu GL, Wang SL, Wei XM, Bai L. Diagnosis and therapy of Gardner syndrome with gastric polyposis: A case report and review of the literature. World J Gastroenterol 2008;14(13): 2121-2123 http://www.wjgnet.com/1007-9327/14/2121.asp
Correspondence to: Shi-Lin Wang, Department of General Surgery, the General Hospital of Airforce PLA, Beijing 100036, China. kzggl@163.com Telephone: +86-10-66928302 Fax: +86-10-66928302
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World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection. It provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th of every month. The WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the title China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.
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