News Release

Would patients with a T tube accompany with duodenal-biliary reflux?

Peer-Reviewed Publication

World Journal of Gastroenterology

The report about sphincter of oddi hypomotility and sphincter of oddi dilation was relatively rare. Whether sphincter of oddi hypomotility and duodenal-biliary reflux existed in these patients and if these patients had abnormal secretion of gastrointestinal hormones need further research.

A research article to be published on 7 July 2008, in the World Journal of Gastroenterology addresses this question. 45 patients with a T tube after cholecystectomy and choledochotomy were divided into reflux group and control group by measuring the amounts of radioactivity of Tc99m-labeled diethylene triamine pentaacetic acid (DTPA) in the bile. The level of plasma motilin and serum gastin of the patients and 12 healthy volunteers were measured by radioimmunoassay. Among them, 34 were selected randomly undergone choledochoscope manometry. Sphincter of Oddi basal pressure (SOBP), amplitude (SOCA), frequency of contractions (SOF), duration of contractions (SOD), duodenal pressure (DP), commen bile duct pressure (CBDP) were scored and analyzed.

They found that many patients with a T tube after cholecystectomy and choledochotomy do have duodenal-biliary reflux. Most of them do have sphincter of Oddi hypomotility and the level of plasma motilin and serum gastrin of them decreased. The level of plasma motilin showed obviously positive correlation with sphincter of Oddi basal pressure and the level of serum gastrin showed apparent positive correlation with sphincter of Oddi basal pressure and common bile duct pressure. The disorder of gastrointestinal hormone secretion may result in sphincter of Oddi dysfunction and the sphincter of Oddi hypomotility caused by it had intimate relationship with duodenal-biliary reflux and recurrence of gallstones.

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Reference: Zhang ZH, Wu SD, Wang B, Su Y, Jin JZ, Kong J, Wang HL. Sphincter of Oddi hypomotility and its relationship with duodenal-biliary reflux, plasma motilin and serum gastrin. World J Gastroenterol 2008; 14(25): 4077-4081
http://www.wjgnet.com/1007-9327/14/4077.asp

Correspondence to: Dr. Shuo-Dong Wu, the No.2 department of general surgery, the Second Affiliated Hospital of China Medical University, 36 block 1, San Hao Street, He-Ping District, Shenyang 110004, Liaoning Province, China. zhangzhenhai410@yahoo.com.cn
Telephone: +86-531-85186363 Fax: +86-531-85186363

About World Journal of Gastroenterology

World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.

About The WJG Press

The WJG Press mainly publishes World Journal of Gastroenterology.


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