The current system of publishing medical and scientific research provides "a distorted view of the reality of scientific data that are generated in the laboratory and clinic," says a team of researchers in this week's PLoS Medicine.
In their Essay, Neal Young (National Institutes of Health, USA), John Ioannidis (Tufts University School of Medicine, USA and University of Ioannina School of Medicine, Greece), and Omar Al-Ubaydli (George Mason University, USA) apply principles from the field of economics to present evidence consistent with a distortion.
There is an "extreme imbalance," they say, between the abundance of supply (the output of basic science laboratories and clinical investigations) and the increasingly limited venues for publication (journals with sufficiently high impact). The result is that only a small proportion of all research results are eventually chosen for publication, and these results are unrepresentative of scientists' repeated samplings of the real world.
The authors argue that there is a moral imperative to reconsider how scientific data are judged and disseminated.
A previous Essay by one of the co-authors, John Ioannidis, which was entitled "Why most published research findings are false" (http://dx.doi.org/10.1371/journal.pmed.0020124) has been the most viewed PLoS Medicine article of all time and was called "an instant cult classic" in a Boston Globe op-ed of July 27 2006 (http://www.boston.com/news/science/articles/2006/07/27/science_and_shams/).
Citation: Young NS, Ioannidis JPA, Al-Ubaydli O (2008) Why current publication practices may distort science. PLoS Med 5(10): e201. doi:10.1371/journal.pmed.0050201
IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE PUBLISHED PAPER: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050201
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-10-ioannidis.pdf
CONTACTS:
John Ioannidis
University of Ioannina School of Medicine
Department of Hygiene and Epidemiology
University Campus
Ioannina, Epirus 45110
Greece
jioannid@cc.uoi.gr
Neal Young
NHLBI
Hematology Branch
Bethesda, 20892-1202
United States of America
youngns@mail.nih.gov
SLC2A9 is a high-capacity urate transporter in humans
Recent genome-wide association scans have found common genetic variants of the gene SLC2A9 to be associated with increased serum urate level and gout, according to a paper published in this week's PLoS Medicine. A team of researchers led by Mark Caulfield from Bart's and The London School of Medicine and Dentistry shows that the SLC2A9 gene, which encodes a glucose transporter, is also a high-capacity urate transporter, and thus possibly a new drug target for gout.
Citation: Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ, et al. (2008) SLC2A9 is a high-capacity urate transporter in humans. PLoS Med 5(9): e197. doi:10.1371/journal.pmed.0050197
IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE PUBLISHED PAPER: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050197
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-10-caulfield.pdf
TRANSLATION OF THE ABSTRACT INTO SPANISH: http://www.plos.org/press/plme-05-10-caulfield-spanish.doc
TRANSLATION OF THE ABSTRACT INTO FRENCH: http://www.plos.org/press/plme-05-10-caulfield-french.doc
TRANSLATION OF THE ABSTRACT INTO ITALIAN: http://www.plos.org/press/plme-05-10-caulfield-italian.doc
Please note that the translations are the work of the authors of the study and PLoS is not responsible for any inaccuracies.
CONTACT:
Mark Caulfield
Bart's and The London School of Medicine and Dentistry
Clinical Pharmacology
Charterhouse Square
London, EC1M 6BQ
United Kingdom
+44 207 882 3403
+442078823408 (fax)
M.J.Caulfield@qmul.ac.uk
Also published this week in the PLoS Medicine magazine section:
Faecal and urinary incontinence after multimodality treatment of rectal cancer
Marilyne Lange and Cornelis van de Velde (Leiden University Medical Centre) discuss the differential diagnosis and management of incontinence after rectal cancer treatment, in a Learning Forum published in this week's PLoS Medicine.
Citation: Lange MM, van de Velde CJH (2008) Faecal and urinary incontinence after multimodality treatment of rectal cancer. PLoS Med 5(10): e202. doi:10.1371/journal.pmed.0050202
IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE PUBLISHED PAPER: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050202
PRESS ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-10-van-de-velde.pdf
CONTACT:
Cornelis van de Velde
Leiden University Medical Centre
Department of Surgery
P.O Box 9600
Leiden, ZH 2300 RC
Netherlands
+31 71 526 2309
+31 71 526 6750 (fax)
c.j.h.van_de_velde@lumc.nl
About PLoS Medicine
PLoS Medicine is an open access, freely available international medical journal. It publishes original research that enhances our understanding of human health and disease, together with commentary and analysis of important global health issues. For more information, visit http://www.plosmedicine.org
About the Public Library of Science
The Public Library of Science (PLoS) is a non-profit organization of scientists and physicians committed to making the world's scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org
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