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Genome sequences of 2 malaria parasites defined

Revealing misdiagnoses and opening way to drug and vaccine development

Research Australia

Professor Alan Cowman, Professor Brendan Crabb, Dr Paul Gilson and Dr Toby Sargeant are WEHI members of international research teams that have made significant discoveries about two deadly malaria parasites, Plasmodium knowlesi and Plasmodium vivax.

Cowman and Sargeant have contributed to defining the genome sequence of the malaria parasite P. knowlesi, which has recently been recognised as a major malaria pathogen of humans. Concurrently, Crabb, Gilson and Sargeant have participated in the genome sequencing of P. vivax, a form of malaria that causes a severely debilitating and sometimes fatal form of the disease.

The natural host of P. knowlesi is the kra monkey, but it has now been established that the parasite is capable of infecting humans. Evidence from the field suggests that human infections by P. knowlesi in South East Asia have been widely misdiagnosed as infections by a comparatively more benign malaria parasite, P. malariae. This has led to unsuitable treatments being prescribed for P. knowlesi victims.

P. knowlesi is the first monkey malaria parasite to be genetically described. It provides new research opportunities for comparisons with the recently completed P. vivax genome and other sequenced Plasmodium genomes. Establishing similarities and differences between the parasites' genomes will assist in the selection of genetic targets for vaccine and drug development.

The notorious malaria parasite P. falciparum is by far the most lethal strain, causing up to 75% of malaria infections and 90% of malaria's three million annual fatalities. The next most deadly strain is P. vivax.

The final three Plasmodium strains - malariae, ovale and knowlesi - are certainly dangerous, but considerably less virulent than falciparum and vivax.

P. vivax is the major cause of malaria outside Africa, being endemic in the wet tropical regions of Asia and Central and South America. The form of malaria caused by P. vivax causes recurring bouts of severe and incapacitating illness, sometimes leading to death.

P. vivax can be transmitted during cooler seasons and in more temperate climates not tolerated by P. falciparum. This extends the reach of P. vivax to half of the world's population. To add to this difficult scenario, drug resistance in P. vivax is becoming more widespread, hindering the management of clinical cases.

As with P. knowlesi, the definition of the genome of P. vivax will enable fresh research into its distinctive biological features, which will in turn help to determine genetic targets for the development of new drugs and vaccines.


The research papers were published in the prestigious international journal Nature on 9 October 2008.

In addition to scientists from WEHI, the international research team for P. knowlesi included scientists from the Wellcome Trust Sanger Institute, UK; the University of Copenhagen, Denmark; the Biomedical Primate Research Centre, the Netherlands; the University of Cambridge, UK; Emory University, Atlanta, GA USA; the University of Liverpool, UK; the University of Glasgow, Scotland; the Harvard School of Public Health, Boston, MA USA; the University of British Columbia, Vancouver, BC Canada; the University of Melbourne, Australia; and the University of Oxford, UK.

In addition to scientists from WEHI, the international research team for P. vivax included scientists from the Institute for Genomic Research/J.Craig Venter Institute, MD USA; the New York School of Medicine, NY USA; the University of South Florida, FL USA; the University of Maryland School of Medicine, MD USA; the University of Washington, WA USA; Purdue University, IN USA; the University of Pennsylvania School of Medicine, PA USA; the Australian Army Malaria Institute, QLD Australia; Prolexys Pharmaceuticals, UT USA; and the European Bioinformatics Institute, UK.

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