News Release

A useful imaging modality for monitoring treatment response to hepatocellular carcinoma

Peer-Reviewed Publication

World Journal of Gastroenterology

TACE has been widely accepted as a choice of treatment for advanced HCC. CT perfusion is a non-invasive and reproducible technique for assessing perfusion changes due to TACE therapy for locally advanced HCC. However, there are few reports on the application of this technique in evaluating the efficacy of TACE based on quantitative analysis of perfusion parameters.

A research article published on October 7, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Professor from Beijing Friendship Hospital affiliated to Capital Medical University used 64-rows multi-detector CT, which can offer a greater coverage (up to 4 cm) of the tumor and portal vein in the scanning range, to prospectively assess the changes in parameters of CT perfusion pre- and post-TACE treatment of HCC in different response groups, and to correlate the changes with various responses to TACE. CT perfusion scan for patients with HCC allows assessment of perfusion changes due to TACE therapy. This study further investigated the correlation between changes in CT perfusion parameters pre- and post-TACE treatment of HCC and various responses to TACE.

In the PR treatment response group, HAP, HAF and HBV of viable tumors were reduced post-TACE compared with before pre-TACE, while no significant difference was observed in HBF, MTT, PS and PVP pre- and post-TACE. In the SD treatment response group, there was no significant difference in perfusion parameters pre- and post-TACE. In the PD treatment group, HAP, HAF, PVP and HBF of viable tumors were significantly increased after TACE compared with pre-TACE, while no significant difference was found in other perfusion parameters pre- and post- TACE. Our findings suggest that changes in CT perfusion parameters in viable tumors are correlated with different response of HCC to TACE. Therefore, CT perfusion imaging is a feasible technique for monitoring response of HCC to TACE.

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Reference: Chen G, Ma DQ, He W, Zhang BF, Zhao LQ. Computed tomography perfusion in evaluating the therapeutic effect of transarterial chemoembolization for hepatocellular carcinoma.World J Gastroenterol 2008; 14(37): 5738-5743 http://www.wjgnet.com/1007-9327/14/5738.asp

Correspondence to: Professor Wen He , Department of Radiology, Beijing Friendship Hospital , Capital Medical University, 95 YongAn Road, Xuan Wu District, Beijing 100050, China. Email: hewen1724@hotmail.com
Telephone: +86-10-63138470 Fax: +86-10-63037216

About World Journal of Gastroenterology

World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.

About The WJG Press

The WJG Press mainly publishes World Journal of Gastroenterology.


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