Public Release: 

Developing a safer form of acetaminophen

Organic Process Research & Development

American Chemical Society

Scientists in Louisiana are reporting development of a process for producing large batches of a new and potentially safer form of acetaminophen, the widely used pain-reliever now the source of growing concern over its potentially toxic effects on the liver. Their study, which could speed development of a next-generation pain-reliever, is scheduled for the July 17 issue of ACS' Organic Process Research & Development, a bi-monthly journal.

In June, an advisory panel of the U. S. Food and Drug Administration recommended banning certain prescription pain relievers containing acetaminophen because of the drug's potential to cause liver damage when used in high doses. Mark Trudell and colleagues note in the study that scientists recently discovered a new form of acetaminophen that has similar potency to the original drug with a lower risk of liver toxicity. But until now, scientists have had difficulty producing this substance in quantities suitable for industrial scale-up.

The researchers describe a simple, efficient method for producing the new pain-reliever using only a few starting materials and a short series of chemical reactions. In laboratory studies, they used the new method to produce multigram quantities of the substance with 99 percent purity. The scientists point out that the new process can be performed on a much larger production level if needed.

###

ARTICLE #1 FOR IMMEDIATE RELEASE
"First Multigram Preparation of SCP-123, A Novel Water-Soluble Analgesic"

DOWNLOAD FULL TEXT ARTICLE : http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/op900113b

CONTACT:
Mark Trudell, Ph.D.
Department of Chemistry
University of New Orleans
New Orleans, Louisiana 70130-6050
Phone: 504-280-7337
Fax: 505-280-6860
Email: mtrudell@uno.edu

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.