News Release

Vardenafil: A potential drug to protect gastric mucosa

Peer-Reviewed Publication

World Journal of Gastroenterology

Indomethacin has been proved by epidemiological and experimental studies to be closely associated with peptic ulcer development. Vardenafil is a potent phosphodiesterase 5 inhibitor and its effects on the gastric mucosa havenot been reported.

A research article to be published in October 28, 2009 in the World Journal of Gastroenterology addresses this question. The research team, led by Dr. Karakaya MD from Zonguldak Karaelmas University, designed an experimental study in rat which they used vardenafil to study gastric mucosal protection against the harmful effects of indomethacin.

Multiple agents have been used to prevent NSAID-induced peptic ulcer. This work is the first experimental study that show the beneficial effects of Vardenafil (a phosphodiesterase type V inhibitor) on NSAID-induced gastric ulcer. The gastroprotective effect of vardenafil against NSAID-induced peptic ulcer is dose-dependent. The study results suggest that vardenafil might be used as a potential therapeutic drug to prevent NSAID-induced gastric ulcer formation.

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Reference: Karakaya K, Hanci V, Bektas S, Can M, Ucan HB, Emre AU, Tascılar O, Ozkocak Turan I, Comert M, Irkorucu O, Karadeniz Cakmak G. Mitigation of indomethacin-induced gastric mucosal lesions by a potent specific type V phosphodiesterase inhibitor. World J Gastroenterol 2009; 15(40): 5091-5096 http://www.wjgnet.com/1007-9327/15/5091.asp

Correspondence to: Kemal Karakaya, MD, Assistant Professor of Surgery, Department of General Surgery, Zonguldak, Karaelmas University, Medical Faculty, 67600 Kozlu, Zonguldak, Turkey. karakayakemal@hotmail.com Telephone: +90-532-6946400 Fax: +90-372-2610155

About World Journal of Gastroenterology

World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H. pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2008 IF: 2.081. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.


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