News Release

Oral sodium phosphate laxative inducing hyperphosphatemia relates with weight?

Peer-Reviewed Publication

World Journal of Gastroenterology

Colon cleansing is used widely for colonoscopic exploration and colonic and gynecological surgery. Oral sodium phosphate (OSP) solution is the osmotic laxative most commonly used for this purpose. It is known that OSP can induce severe hyperphosphatemia and hypocalcemia due to excessive absorption of phosphates, and there have been reports of deaths and irreversible dialysis-requiring renal insufficiency. However, no prospective studies have investigated the prevalence of hyperphosphatemia in low-risk patients.

A research article to be published on December 21, 2009 in the World Journal of Gastroenterology addresses this question. A research team from Argentina recruited one hundred consecutive ASA Ⅰ-Ⅱ individuals aged 35-74 years to study the frequency of hyperphosphatemia following the administration of OSP.

They found that in low-risk, well-hydrated patients, hyperphosphatemia following standard OSP doses is related to weight.

Their results suggest performing preoperative evaluation aimed at avoiding administration of OSP laxatives to patients at risk; reducing the dose of OSP in patients with low weight; and avoiding dehydration with an adequate oral intake of clear liquids.

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Reference: Casais MN, Rosa-Diez G, Pérez S, Mansilla EN, Bravo S, Bonofiglio FC. Hyperphosphatemia after sodium phosphate laxatives in low risk patients: Prospective study. World J Gastroenterol 2009; 15(47): 5960-5965 http://www.wjgnet.com/1007-9327/15/5960.asp

Correspondence to: Marcela Noemi Casais, MD, Department of Anesthesia, Preoperative Evaluation Section, Hospital Italiano de Buenos Aires, Rivadavia 4965, 9C, Buenos Aires, Argentina. marcela.casais@hospitalitaliano.org.ar Telephone: +54-11-49018829 Fax: +54-11-49018829

About World Journal of Gastroenterology

World Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2008 IF: 2.081. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.


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