Those looking for a new treatment for a range of inflammatory diseases like arthritis, multiple sclerosis, inflammatory bowel disease, and lupus may need to look no further than a drug already available for treating cancer. In a research report published in the July 2010 print issue of the Journal of Leukocyte Biology (http://www.
"Unfortunately, there are a lot of people who are suffering from autoimmune and inflammatory disease," said Koichi Yanaba, M.D., Ph.D., a scientist from the Department of Dermatology at Nagasaki University Graduate School of Biomedical Sciences who was involved in the research. "We believe that this new-type remedy for autoimmune and inflammatory disease could successfully treat them in the near future."
To make this discovery, scientists used two groups of mice--the first treated with bortezomib and the second with saline. Researchers induced contact hypersensitivity reaction with oxazolone, a chemical allergen used for immunological experiments and found that bortezomib significantly inhibited the contact hypersensitivity responses. Results strongly suggest that bortezomib treatment enhanced T cell death by inhibiting NF-kappa B activation, which plays a key role in regulating the immune response to infection. This in turn led to the suppression of inflammatory responses in immune cells by reducing interferon-gamma production.
"Any time you learn that a drug already on the market has the potential to be used for more illnesses than originally thought, it's a hopeful discovery," said Luis J. Montaner, D.V.M., M.Sc., D.Phil., Editor-in-Chief of the Journal of Leukocyte Biology, "Even if this drug is not quite as successful in humans, it raises the possibility that a similar compound could be created which would be more successful."
The Journal of Leukocyte Biology (http://www.
Details: Koichi Yanaba, Ayumi Yoshizaki, Eiji Muroi, Toshihide Hara, Fumihide Ogawa, Kazuhiro Shimizu, and Shinichi Sato. The proteasome inhibitor bortezomib inhibits T cell-dependent inflammatory responses. J Leukoc Biol 2010 88: 117-122. DOI: 10.1189/jlb.1009666 ; http://www.